The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer

C. L. Downey, S. A. Simpkins, J. White, D. L. Holliday, J. L. Jones, L. B. Jordan, J. Kulka, S. Pollock, S. S. Rajan, H. H. Thygesen, A. M. Hanby, V Speirs

Research output: Contribution to journalArticle

40 Citations (Scopus)
4 Downloads (Pure)

Abstract

BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.

METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.

RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.

CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.

Original languageEnglish
Pages (from-to)1744-1747
Number of pages4
JournalBritish Journal of Cancer
Volume110
Issue number7
Early online date18 Feb 2014
DOIs
Publication statusPublished - 1 Apr 2014

Fingerprint

Estrogen Receptors
Breast Neoplasms
Triple Negative Breast Neoplasms
Male Breast Neoplasms
Neoplasms
Recurrence
Hematoxylin
Eosine Yellowish-(YS)
Multivariate Analysis

Keywords

  • breast cancer
  • male
  • stroma
  • tumour-stroma ratio
  • prognosis

Cite this

Downey, C. L., Simpkins, S. A., White, J., Holliday, D. L., Jones, J. L., Jordan, L. B., ... Speirs, V. (2014). The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer. British Journal of Cancer, 110(7), 1744-1747. https://doi.org/10.1038/bjc.2014.69

The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer. / Downey, C. L.; Simpkins, S. A.; White, J.; Holliday, D. L.; Jones, J. L.; Jordan, L. B.; Kulka, J.; Pollock, S.; Rajan, S. S.; Thygesen, H. H.; Hanby, A. M.; Speirs, V.

In: British Journal of Cancer, Vol. 110, No. 7, 01.04.2014, p. 1744-1747.

Research output: Contribution to journalArticle

Downey, CL, Simpkins, SA, White, J, Holliday, DL, Jones, JL, Jordan, LB, Kulka, J, Pollock, S, Rajan, SS, Thygesen, HH, Hanby, AM & Speirs, V 2014, 'The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer' British Journal of Cancer, vol. 110, no. 7, pp. 1744-1747. https://doi.org/10.1038/bjc.2014.69
Downey CL, Simpkins SA, White J, Holliday DL, Jones JL, Jordan LB et al. The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer. British Journal of Cancer. 2014 Apr 1;110(7):1744-1747. https://doi.org/10.1038/bjc.2014.69
Downey, C. L. ; Simpkins, S. A. ; White, J. ; Holliday, D. L. ; Jones, J. L. ; Jordan, L. B. ; Kulka, J. ; Pollock, S. ; Rajan, S. S. ; Thygesen, H. H. ; Hanby, A. M. ; Speirs, V. / The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer. In: British Journal of Cancer. 2014 ; Vol. 110, No. 7. pp. 1744-1747.
@article{beed91a76b3644f2b93b40a1f2939d72,
title = "The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer",
abstract = "BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49{\%}) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49{\%} stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.",
keywords = "breast cancer, male, stroma, tumour-stroma ratio, prognosis",
author = "Downey, {C. L.} and Simpkins, {S. A.} and J. White and Holliday, {D. L.} and Jones, {J. L.} and Jordan, {L. B.} and J. Kulka and S. Pollock and Rajan, {S. S.} and Thygesen, {H. H.} and Hanby, {A. M.} and V Speirs",
note = "We are grateful to Breast Cancer Campaign for funding our collection of male breast carcinomas and for supporting DLH and SP. SAS was funded by the Wolfson Foundation and a Wellcome Trust Vacation Scholarship. HHT was funded by Cancer Research UK. We convey special thanks to members of the Leeds Breast Team for input and support at various stages of this project.",
year = "2014",
month = "4",
day = "1",
doi = "10.1038/bjc.2014.69",
language = "English",
volume = "110",
pages = "1744--1747",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer

AU - Downey, C. L.

AU - Simpkins, S. A.

AU - White, J.

AU - Holliday, D. L.

AU - Jones, J. L.

AU - Jordan, L. B.

AU - Kulka, J.

AU - Pollock, S.

AU - Rajan, S. S.

AU - Thygesen, H. H.

AU - Hanby, A. M.

AU - Speirs, V

N1 - We are grateful to Breast Cancer Campaign for funding our collection of male breast carcinomas and for supporting DLH and SP. SAS was funded by the Wolfson Foundation and a Wellcome Trust Vacation Scholarship. HHT was funded by Cancer Research UK. We convey special thanks to members of the Leeds Breast Team for input and support at various stages of this project.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.

AB - BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.

KW - breast cancer

KW - male

KW - stroma

KW - tumour-stroma ratio

KW - prognosis

U2 - 10.1038/bjc.2014.69

DO - 10.1038/bjc.2014.69

M3 - Article

VL - 110

SP - 1744

EP - 1747

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 7

ER -