Abstract
BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.
CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.
| Original language | English |
|---|---|
| Pages (from-to) | 1744-1747 |
| Number of pages | 4 |
| Journal | British Journal of Cancer |
| Volume | 110 |
| Issue number | 7 |
| Early online date | 18 Feb 2014 |
| DOIs | |
| Publication status | Published - 1 Apr 2014 |
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Keywords
- breast cancer
- male
- stroma
- tumour-stroma ratio
- prognosis
Cite this
The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer. / Downey, C. L.; Simpkins, S. A.; White, J.; Holliday, D. L.; Jones, J. L.; Jordan, L. B.; Kulka, J.; Pollock, S.; Rajan, S. S.; Thygesen, H. H.; Hanby, A. M.; Speirs, V.
In: British Journal of Cancer, Vol. 110, No. 7, 01.04.2014, p. 1744-1747.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer
AU - Downey, C. L.
AU - Simpkins, S. A.
AU - White, J.
AU - Holliday, D. L.
AU - Jones, J. L.
AU - Jordan, L. B.
AU - Kulka, J.
AU - Pollock, S.
AU - Rajan, S. S.
AU - Thygesen, H. H.
AU - Hanby, A. M.
AU - Speirs, V
N1 - We are grateful to Breast Cancer Campaign for funding our collection of male breast carcinomas and for supporting DLH and SP. SAS was funded by the Wolfson Foundation and a Wellcome Trust Vacation Scholarship. HHT was funded by Cancer Research UK. We convey special thanks to members of the Leeds Breast Team for input and support at various stages of this project.
PY - 2014/4/1
Y1 - 2014/4/1
N2 - BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.
AB - BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.
KW - breast cancer
KW - male
KW - stroma
KW - tumour-stroma ratio
KW - prognosis
U2 - 10.1038/bjc.2014.69
DO - 10.1038/bjc.2014.69
M3 - Article
C2 - 24548861
VL - 110
SP - 1744
EP - 1747
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 7
ER -