The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer

C. L. Downey; S. A. Simpkins; J. White; D. L. Holliday; J. L. Jones; L. B. Jordan; J. Kulka; S. Pollock; S. S. Rajan; H. H. Thygesen; A. M. Hanby; V Speirs

doi:10.1038/bjc.2014.69

The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer

C. L. Downey, S. A. Simpkins, J. White, D. L. Holliday, J. L. Jones, L. B. Jordan, J. Kulka, S. Pollock, S. S. Rajan, H. H. Thygesen, A. M. Hanby, V Speirs

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Abstract

BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.

METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.

RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.

CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.

Original language	English
Pages (from-to)	1744-1747
Number of pages	4
Journal	British Journal of Cancer
Volume	110
Issue number	7
Early online date	18 Feb 2014
DOIs	https://doi.org/10.1038/bjc.2014.69
Publication status	Published - 1 Apr 2014

Keywords

breast cancer
male
stroma
tumour-stroma ratio
prognosis

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The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer
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Downey, C. L., Simpkins, S. A., White, J., Holliday, D. L., Jones, J. L., Jordan, L. B., Kulka, J., Pollock, S., Rajan, S. S., Thygesen, H. H., Hanby, A. M., & Speirs, V. (2014). The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer. British Journal of Cancer, 110(7), 1744-1747. https://doi.org/10.1038/bjc.2014.69

The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer. / Downey, C. L.; Simpkins, S. A.; White, J.; Holliday, D. L.; Jones, J. L.; Jordan, L. B.; Kulka, J.; Pollock, S.; Rajan, S. S.; Thygesen, H. H.; Hanby, A. M.; Speirs, V.

In: British Journal of Cancer, Vol. 110, No. 7, 01.04.2014, p. 1744-1747.

Research output: Contribution to journal › Article

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title = "The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer",

abstract = "BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.",

keywords = "breast cancer, male, stroma, tumour-stroma ratio, prognosis",

author = "Downey, {C. L.} and Simpkins, {S. A.} and J. White and Holliday, {D. L.} and Jones, {J. L.} and Jordan, {L. B.} and J. Kulka and S. Pollock and Rajan, {S. S.} and Thygesen, {H. H.} and Hanby, {A. M.} and V Speirs",

note = "We are grateful to Breast Cancer Campaign for funding our collection of male breast carcinomas and for supporting DLH and SP. SAS was funded by the Wolfson Foundation and a Wellcome Trust Vacation Scholarship. HHT was funded by Cancer Research UK. We convey special thanks to members of the Leeds Breast Team for input and support at various stages of this project.",

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T1 - The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer

AU - Downey, C. L.

AU - Simpkins, S. A.

AU - White, J.

AU - Holliday, D. L.

AU - Jones, J. L.

AU - Jordan, L. B.

AU - Kulka, J.

AU - Pollock, S.

AU - Rajan, S. S.

AU - Thygesen, H. H.

AU - Hanby, A. M.

AU - Speirs, V

N1 - We are grateful to Breast Cancer Campaign for funding our collection of male breast carcinomas and for supporting DLH and SP. SAS was funded by the Wolfson Foundation and a Wellcome Trust Vacation Scholarship. HHT was funded by Cancer Research UK. We convey special thanks to members of the Leeds Breast Team for input and support at various stages of this project.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.

AB - BACKGROUND: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.METHODS: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.RESULTS: Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.CONCLUSIONS: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.

KW - breast cancer

KW - male

KW - stroma

KW - tumour-stroma ratio

KW - prognosis

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