The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort

Lucy K M Bain, Phyo K Myint, Amy Jennings, Marleen A H Lentjes, Robert N Luben, Kay-Tee Khaw, Nick J Wareham, Ailsa A Welch

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Abstract

BACKGROUND: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population.

METHODS: We conducted cross-sectional analyses in a case-cohort study of 4443, men and women aged 40-75, representative of 25,639 participants years of the EPIC (European Prospective Investigation into Cancer)-Norfolk cohort. The cohort included 928 stroke cases (42,556.5person years). Dietary data from 7day food diaries were analysed using multivariate regression to assess associations between quintiles or data-derived categories of dietary magnesium intake and BP, TC and stroke risk, adjusted for relevant confounders.

RESULTS: We observed differences of -7mmHg systolic BP (P trend≤0.01) and -3.8mmHg diastolic BP (P trend=0.01) between extreme intakes of magnesium in men, a significant inverse association with TC was observed (P trend=0.02 men and 0.04 women). Compared to the bottom 10%, the top 30% of magnesium intake was associated with a 41% relative reduction in stroke risk (HR 0.59; 95% CI 0.38-0.93) in men.

CONCLUSIONS: Lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention.

Original languageEnglish
Pages (from-to)108-114
Number of pages7
JournalInternational Journal of Cardiology
Volume196
Early online date31 May 2015
DOIs
Publication statusPublished - 1 Oct 2015

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Magnesium
Stroke
Cholesterol
Blood Pressure
Neoplasms
Hypertension
Diet Records
Primary Prevention
Population
Cohort Studies
Cross-Sectional Studies

Keywords

  • magnesium
  • stroke
  • hypertension
  • hypercholesterolemia

Cite this

The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort. / Bain, Lucy K M; Myint, Phyo K; Jennings, Amy; Lentjes, Marleen A H; Luben, Robert N; Khaw, Kay-Tee; Wareham, Nick J; Welch, Ailsa A.

In: International Journal of Cardiology, Vol. 196, 01.10.2015, p. 108-114.

Research output: Contribution to journalArticle

Bain, Lucy K M ; Myint, Phyo K ; Jennings, Amy ; Lentjes, Marleen A H ; Luben, Robert N ; Khaw, Kay-Tee ; Wareham, Nick J ; Welch, Ailsa A. / The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort. In: International Journal of Cardiology. 2015 ; Vol. 196. pp. 108-114.
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abstract = "BACKGROUND: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population.METHODS: We conducted cross-sectional analyses in a case-cohort study of 4443, men and women aged 40-75, representative of 25,639 participants years of the EPIC (European Prospective Investigation into Cancer)-Norfolk cohort. The cohort included 928 stroke cases (42,556.5person years). Dietary data from 7day food diaries were analysed using multivariate regression to assess associations between quintiles or data-derived categories of dietary magnesium intake and BP, TC and stroke risk, adjusted for relevant confounders.RESULTS: We observed differences of -7mmHg systolic BP (P trend≤0.01) and -3.8mmHg diastolic BP (P trend=0.01) between extreme intakes of magnesium in men, a significant inverse association with TC was observed (P trend=0.02 men and 0.04 women). Compared to the bottom 10{\%}, the top 30{\%} of magnesium intake was associated with a 41{\%} relative reduction in stroke risk (HR 0.59; 95{\%} CI 0.38-0.93) in men.CONCLUSIONS: Lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention.",
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AU - Bain, Lucy K M

AU - Myint, Phyo K

AU - Jennings, Amy

AU - Lentjes, Marleen A H

AU - Luben, Robert N

AU - Khaw, Kay-Tee

AU - Wareham, Nick J

AU - Welch, Ailsa A

N1 - Copyright © 2015. Published by Elsevier Ireland Ltd. Acknowledgements The authors wish to thank all staff and participants who are part of the EPIC-Norfolk study.

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N2 - BACKGROUND: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population.METHODS: We conducted cross-sectional analyses in a case-cohort study of 4443, men and women aged 40-75, representative of 25,639 participants years of the EPIC (European Prospective Investigation into Cancer)-Norfolk cohort. The cohort included 928 stroke cases (42,556.5person years). Dietary data from 7day food diaries were analysed using multivariate regression to assess associations between quintiles or data-derived categories of dietary magnesium intake and BP, TC and stroke risk, adjusted for relevant confounders.RESULTS: We observed differences of -7mmHg systolic BP (P trend≤0.01) and -3.8mmHg diastolic BP (P trend=0.01) between extreme intakes of magnesium in men, a significant inverse association with TC was observed (P trend=0.02 men and 0.04 women). Compared to the bottom 10%, the top 30% of magnesium intake was associated with a 41% relative reduction in stroke risk (HR 0.59; 95% CI 0.38-0.93) in men.CONCLUSIONS: Lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention.

AB - BACKGROUND: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population.METHODS: We conducted cross-sectional analyses in a case-cohort study of 4443, men and women aged 40-75, representative of 25,639 participants years of the EPIC (European Prospective Investigation into Cancer)-Norfolk cohort. The cohort included 928 stroke cases (42,556.5person years). Dietary data from 7day food diaries were analysed using multivariate regression to assess associations between quintiles or data-derived categories of dietary magnesium intake and BP, TC and stroke risk, adjusted for relevant confounders.RESULTS: We observed differences of -7mmHg systolic BP (P trend≤0.01) and -3.8mmHg diastolic BP (P trend=0.01) between extreme intakes of magnesium in men, a significant inverse association with TC was observed (P trend=0.02 men and 0.04 women). Compared to the bottom 10%, the top 30% of magnesium intake was associated with a 41% relative reduction in stroke risk (HR 0.59; 95% CI 0.38-0.93) in men.CONCLUSIONS: Lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention.

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