The relationship between inadvertent ingestion and dermal exposure pathways: a new integrated conceptual model and a database of dermal and oral transfer efficiencies

Melanie Gorman Ng, Sean Semple, John Cherrie, Yvette Christopher, Christine Northage, Erik Tielemans, Violaine Veroughstraete, Martie Van Tongeren

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Occupational inadvertent ingestion exposure is ingestion exposure due to contact between the mouth and contaminated hands or objects. Although individuals are typically oblivious to their exposure by this route, it is a potentially significant source of occupational exposure for some substances. Due to the continual flux of saliva through the oral cavity and the non-specificity of biological monitoring to routes of exposure, direct measurement of exposure by the inadvertent ingestion route is challenging; predictive models may be required to assess exposure. The work described in this manuscript has been carried out as part of a project to develop a predictive model for estimating inadvertent ingestion exposure in the workplace. As inadvertent ingestion exposure mainly arises from hand-to-mouth contact, it is closely linked to dermal exposure. We present a new integrated conceptual model for dermal and inadvertent ingestion exposure that should help to increase our understanding of ingestion exposure and our ability to simultaneously estimate exposure by the dermal and ingestion routes. The conceptual model consists of eight compartments (source, air, surface contaminant layer, outer clothing contaminant layer, inner clothing contaminant layer, hands and arms layer, perioral layer, and oral cavity) and nine mass transport processes (emission, deposition, resuspension or evaporation, transfer, removal, redistribution, decontamination, penetration and/or permeation, and swallowing) that describe event-based movement of substances between compartments (e.g. emission, deposition, etc.). This conceptual model is intended to guide the development of predictive exposure models that estimate exposure from both the dermal and the inadvertent ingestion pathways. For exposure by these pathways the efficiency of transfer of materials between compartments (for example from surfaces to hands, or from hands to the mouth) are important determinants of exposure. A database of transfer efficiency data relevant for dermal and inadvertent ingestion exposure was developed, containing 534 empirically measured transfer efficiencies measured between 1980 and 2010 and reported in the peer-reviewed and grey literature. The majority of the reported transfer efficiencies (84%) relate to transfer between surfaces and hands, but the database also includes efficiencies for other transfer scenarios, including surface-to-glove, hand-to-mouth, and skin-to-skin. While the conceptual model can provide a framework for a predictive exposure assessment model, the database provides detailed information on transfer efficiencies between the various compartments. Together, the conceptual model and the database provide a basis for the development of a quantitative tool to estimate inadvertent ingestion exposure in the workplace.
Original languageEnglish
Pages (from-to)1000-1012
Number of pages13
JournalAnnals of Occupational Hygiene
Volume56
Issue number9
Early online date17 Jul 2012
DOIs
Publication statusPublished - Nov 2012

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Eating
Databases
Skin
Hand
Mouth
Clothing
Workplace
Literature
Decontamination
Environmental Monitoring
Occupational Exposure
Deglutition
Saliva
Arm
Air

Keywords

  • dermal exposure
  • determinants of exposure
  • exposure modelling
  • inadvertent ingestion exposure
  • occupational exposure

Cite this

The relationship between inadvertent ingestion and dermal exposure pathways : a new integrated conceptual model and a database of dermal and oral transfer efficiencies. / Gorman Ng, Melanie; Semple, Sean; Cherrie, John; Christopher, Yvette; Northage, Christine; Tielemans, Erik; Veroughstraete, Violaine; Van Tongeren, Martie.

In: Annals of Occupational Hygiene, Vol. 56, No. 9, 11.2012, p. 1000-1012.

Research output: Contribution to journalArticle

Gorman Ng, M, Semple, S, Cherrie, J, Christopher, Y, Northage, C, Tielemans, E, Veroughstraete, V & Van Tongeren, M 2012, 'The relationship between inadvertent ingestion and dermal exposure pathways: a new integrated conceptual model and a database of dermal and oral transfer efficiencies' Annals of Occupational Hygiene, vol. 56, no. 9, pp. 1000-1012. https://doi.org/10.1093/annhyg/mes041
Gorman Ng, Melanie ; Semple, Sean ; Cherrie, John ; Christopher, Yvette ; Northage, Christine ; Tielemans, Erik ; Veroughstraete, Violaine ; Van Tongeren, Martie. / The relationship between inadvertent ingestion and dermal exposure pathways : a new integrated conceptual model and a database of dermal and oral transfer efficiencies. In: Annals of Occupational Hygiene. 2012 ; Vol. 56, No. 9. pp. 1000-1012.
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