The relationship between infant airway function, childhood airway responsiveness, and asthma

Stephen William Turner, L. J. Palmer, P. J. Rye, N. A. Gibson, P. K. Judge, M. Cox, S. Young, J. Goldblatt, L. I. Landau, P. N. Le Souef

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The relationship between reduced pulmonary function in early life and persistent wheeze (PW) in school-aged children remains uncertain. In this study, VmaxFRC was assessed at 1 month of age, and the presence of wheeze up to 11 years of age was prospectively identified. At 11 years of age, airway responsiveness (AR) to inhaled histamine and atopy were assessed. Recent wheeze at 11 years of age was associated with a reduced mean z score for VmaxFRC at 1 month of age (-0.41 [SD 0.91], n = 31) compared with no recent wheeze (0.04 [SD 1.00], n = 153, p = 0.03). Wheeze between 4 and 6 years that persisted at 11 years (PW) was most prevalent among those with reduced VmaxFRC at 1 month and atopy aged 11 years (p 0.002) or reduced VmaxFRC and increased AR aged 11 years (p = 0.015). When all factors were considered, reduced VmaxFRC at 1 month (p = 0.03) and increased AR aged 11 years (p < 0.001) were independently associated with PW (n = 17) compared with other outcomes (n = 129). Reduced airway function present in early infancy is associated with PW at 11 years of age, and this relationship is independent of the effect of increased AR and atopy in childhood.

Original languageEnglish
Pages (from-to)921-927
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume169
DOIs
Publication statusPublished - Apr 2004

Keywords

  • respiratory sounds
  • respiratory function tests
  • longitudinal study
  • infant
  • LUNG-FUNCTION
  • BRONCHIAL RESPONSIVENESS
  • RESPIRATORY SYMPTOMS
  • WHEEZING DISORDERS
  • MATERNAL SMOKING
  • RISK FACTOR
  • ADULT LIFE
  • CHILDREN
  • AGE
  • FLOW

Cite this

The relationship between infant airway function, childhood airway responsiveness, and asthma. / Turner, Stephen William; Palmer, L. J.; Rye, P. J.; Gibson, N. A.; Judge, P. K.; Cox, M.; Young, S.; Goldblatt, J.; Landau, L. I.; Le Souef, P. N.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 169, 04.2004, p. 921-927.

Research output: Contribution to journalArticle

Turner, SW, Palmer, LJ, Rye, PJ, Gibson, NA, Judge, PK, Cox, M, Young, S, Goldblatt, J, Landau, LI & Le Souef, PN 2004, 'The relationship between infant airway function, childhood airway responsiveness, and asthma', American Journal of Respiratory and Critical Care Medicine, vol. 169, pp. 921-927. https://doi.org/10.1164/rccm.200307-891OC
Turner, Stephen William ; Palmer, L. J. ; Rye, P. J. ; Gibson, N. A. ; Judge, P. K. ; Cox, M. ; Young, S. ; Goldblatt, J. ; Landau, L. I. ; Le Souef, P. N. / The relationship between infant airway function, childhood airway responsiveness, and asthma. In: American Journal of Respiratory and Critical Care Medicine. 2004 ; Vol. 169. pp. 921-927.
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AU - Turner, Stephen William

AU - Palmer, L. J.

AU - Rye, P. J.

AU - Gibson, N. A.

AU - Judge, P. K.

AU - Cox, M.

AU - Young, S.

AU - Goldblatt, J.

AU - Landau, L. I.

AU - Le Souef, P. N.

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N2 - The relationship between reduced pulmonary function in early life and persistent wheeze (PW) in school-aged children remains uncertain. In this study, VmaxFRC was assessed at 1 month of age, and the presence of wheeze up to 11 years of age was prospectively identified. At 11 years of age, airway responsiveness (AR) to inhaled histamine and atopy were assessed. Recent wheeze at 11 years of age was associated with a reduced mean z score for VmaxFRC at 1 month of age (-0.41 [SD 0.91], n = 31) compared with no recent wheeze (0.04 [SD 1.00], n = 153, p = 0.03). Wheeze between 4 and 6 years that persisted at 11 years (PW) was most prevalent among those with reduced VmaxFRC at 1 month and atopy aged 11 years (p 0.002) or reduced VmaxFRC and increased AR aged 11 years (p = 0.015). When all factors were considered, reduced VmaxFRC at 1 month (p = 0.03) and increased AR aged 11 years (p < 0.001) were independently associated with PW (n = 17) compared with other outcomes (n = 129). Reduced airway function present in early infancy is associated with PW at 11 years of age, and this relationship is independent of the effect of increased AR and atopy in childhood.

AB - The relationship between reduced pulmonary function in early life and persistent wheeze (PW) in school-aged children remains uncertain. In this study, VmaxFRC was assessed at 1 month of age, and the presence of wheeze up to 11 years of age was prospectively identified. At 11 years of age, airway responsiveness (AR) to inhaled histamine and atopy were assessed. Recent wheeze at 11 years of age was associated with a reduced mean z score for VmaxFRC at 1 month of age (-0.41 [SD 0.91], n = 31) compared with no recent wheeze (0.04 [SD 1.00], n = 153, p = 0.03). Wheeze between 4 and 6 years that persisted at 11 years (PW) was most prevalent among those with reduced VmaxFRC at 1 month and atopy aged 11 years (p 0.002) or reduced VmaxFRC and increased AR aged 11 years (p = 0.015). When all factors were considered, reduced VmaxFRC at 1 month (p = 0.03) and increased AR aged 11 years (p < 0.001) were independently associated with PW (n = 17) compared with other outcomes (n = 129). Reduced airway function present in early infancy is associated with PW at 11 years of age, and this relationship is independent of the effect of increased AR and atopy in childhood.

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KW - infant

KW - LUNG-FUNCTION

KW - BRONCHIAL RESPONSIVENESS

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KW - WHEEZING DISORDERS

KW - MATERNAL SMOKING

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KW - ADULT LIFE

KW - CHILDREN

KW - AGE

KW - FLOW

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JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

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