The relationship between major histocompatibility receptors and innate immunity in teleost fish.

B. Dixon, Rene Josephus Maria Stet

    Research output: Contribution to journalArticle

    57 Citations (Scopus)

    Abstract

    Studies of the innate immune system have recently shown that, in addition to its role in producing the primary response that slows down pathogens, it may also play an important role in initiating and directing the type of response that the adaptive immune system makes. These discoveries have shown a complex web of control containing new roles for the innate immune system in organizing responses of T-cell to antigens being presented by major histocompatibility receptors, as well as new roles for those receptors in innate immune responses. Both of these activities are managed through feedback networks involving elements of both the innate and adaptive immune system. This paper will discuss these newly discovered interactions and how they are influencing current theories regarding the initiation of adaptive immune responses. In particular, it will highlight the recent progress that is being made towards understanding these relationships in the immune systems of teleost fish. (C) 2001 Elsevier Science Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)683-699
    Number of pages16
    JournalDevelopmental and Comparative Immunology
    Volume25
    DOIs
    Publication statusPublished - 2001

    Keywords

    • innate immunity
    • adaptive immunity
    • major histocompatibility receptors
    • T-cell receptors
    • pathogen
    • antigen presentation
    • KIR
    • natural killer cell
    • natural cytotoxicity receptors
    • COMPLEX CLASS-I
    • NATURAL-KILLER-CELLS
    • SHOCK-PROTEIN GP96
    • ANTIGEN-PRESENTING MOLECULES
    • CYTOTOXIC T-LYMPHOCYTES
    • HUMAN NK CELLS
    • HEAT-SHOCK
    • TRIGGERING RECEPTOR
    • DENDRITIC CELLS
    • CRYSTAL-STRUCTURE

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