The Relationship Between Nutritional Status at the Time of Stroke on Adverse Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

Lorenzo de Paola, Tiberiu Pana, Ben Carter, Roy Soiza, Mohannad W. Kafri, John F Potter, Mamas A Mamas, Phyo Kyaw Myint* (Corresponding Author), Arnav Mehta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Context and Objective: The impact of existing malnutrition on stroke outcomes is poorly recognised and treated. Evidence was systematically reviewed and quantified by meta-analysis.
Methods: MEDLINE, EMBASE and Web of Science were searched from inception to 11
January 2021 and updated in July. Prospective cohort studies, in English, evaluating anthropometric and biomarkers of nutrition on stroke outcomes were included. Risk of bias was assessed using the Scottish Intercollegiate Guidelines Network checklist.

Results: Twenty-six studies (n=156,249) were eligible (follow-up: one month-14 years). Underweight patients had increased risk of long-term mortality (adjusted hazard ratio=1.65,1.41-1.95), whilst overweight (0.80,0.74-0.86) and obese patients (0.80,0.75-0.85) had decreased risk compared to normal weight. Odds of mortality decreased in those with high serum albumin (odds ratio=0.29,0.18-0.48) and increased with low serum albumin (odds ratio=3.46,1.78-6.74) compared to normal serum albumin (30-35g/L). Being malnourished compared to well-nourished, as assessed by the Subjective Global Assessment (SGA) or by a combination of anthropometric and biochemical markers increased all-cause mortality (odds ratio=2.38,1.85-3.06) and poor functional status (adjusted odds ratio=2.21,1.40-3.49).
Conclusion: Nutritional status at the time of stroke predicts adverse stroke outcomes.
Original languageEnglish
JournalNutrition Reviews
Early online date27 May 2022
DOIs
Publication statusE-pub ahead of print - 27 May 2022

Keywords

  • malnutrition
  • stroke and prognosis

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