The relationship of C-reactive protein to obesity-related depressive symptoms: a longitudinal study

Michael Daly

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: Obesity has been shown to produce a state of systematic low‐grade inflammation that may have detrimental neuropsychiatric effects.Design and Methods:Longitudinal associations between obesity, inflammation, and depressive symptoms amongst a cohort of older English adults over 4 years of follow‐up were examined. Participants were 3,891 obese and non obese people drawn from the English longitudinal study of ageing (ELSA) [aged 64.9 (SD = 8.8) years, 44.6% men]. Depressive symptoms were assessed at baseline and after 4 years of follow‐up using the eight‐item center for epidemiological studies—depression scale (CES‐D).Results:Approximately 26.3% (N = 1,025) of the sample were categorized as obese at baseline. Obesity at baseline was associated with elevated levels of depressive symptoms at follow‐up (P < 0.001), in analyses that adjusted for depression levels at baseline and socio demographic and background variables including the prevalence of permanent illness/disability, alcohol consumption, sedentary behavior, and smoking. In addition, C‐reactive protein (CRP) concentrations at baseline were independently associated with CES‐D depression scores at follow‐up (P = 0.008) in fully adjusted analyses. Subsequent mediation analyses revealed that CRP levels explained ∼20% of the obesity‐related longitudinal change in depression scores. Conclusion:These data suggest that chronic inflammation may be a key determinant of depressive symptoms in obesity.
Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalObesity
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

C-Reactive Protein
Longitudinal Studies
Obesity
Depression
Inflammation
Alcohol Drinking
Proteins
Smoking
Demography

Keywords

  • Obesity
  • Depression

Cite this

The relationship of C-reactive protein to obesity-related depressive symptoms: a longitudinal study. / Daly, Michael.

In: Obesity, Vol. 21, No. 2, 02.2013, p. 248-250.

Research output: Contribution to journalArticle

@article{1ba9ec577350470588f5ded4d2885fdf,
title = "The relationship of C-reactive protein to obesity-related depressive symptoms: a longitudinal study",
abstract = "Objective: Obesity has been shown to produce a state of systematic low‐grade inflammation that may have detrimental neuropsychiatric effects.Design and Methods:Longitudinal associations between obesity, inflammation, and depressive symptoms amongst a cohort of older English adults over 4 years of follow‐up were examined. Participants were 3,891 obese and non obese people drawn from the English longitudinal study of ageing (ELSA) [aged 64.9 (SD = 8.8) years, 44.6{\%} men]. Depressive symptoms were assessed at baseline and after 4 years of follow‐up using the eight‐item center for epidemiological studies—depression scale (CES‐D).Results:Approximately 26.3{\%} (N = 1,025) of the sample were categorized as obese at baseline. Obesity at baseline was associated with elevated levels of depressive symptoms at follow‐up (P < 0.001), in analyses that adjusted for depression levels at baseline and socio demographic and background variables including the prevalence of permanent illness/disability, alcohol consumption, sedentary behavior, and smoking. In addition, C‐reactive protein (CRP) concentrations at baseline were independently associated with CES‐D depression scores at follow‐up (P = 0.008) in fully adjusted analyses. Subsequent mediation analyses revealed that CRP levels explained ∼20{\%} of the obesity‐related longitudinal change in depression scores. Conclusion:These data suggest that chronic inflammation may be a key determinant of depressive symptoms in obesity.",
keywords = "Obesity, Depression",
author = "Michael Daly",
note = "Funding agencies: This research was supported by a European Commission co‐funded Government of Ireland CARA Postdoctoral Mobility Fellowship.",
year = "2013",
month = "2",
doi = "10.1002/oby.20051",
language = "English",
volume = "21",
pages = "248--250",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - The relationship of C-reactive protein to obesity-related depressive symptoms: a longitudinal study

AU - Daly, Michael

N1 - Funding agencies: This research was supported by a European Commission co‐funded Government of Ireland CARA Postdoctoral Mobility Fellowship.

PY - 2013/2

Y1 - 2013/2

N2 - Objective: Obesity has been shown to produce a state of systematic low‐grade inflammation that may have detrimental neuropsychiatric effects.Design and Methods:Longitudinal associations between obesity, inflammation, and depressive symptoms amongst a cohort of older English adults over 4 years of follow‐up were examined. Participants were 3,891 obese and non obese people drawn from the English longitudinal study of ageing (ELSA) [aged 64.9 (SD = 8.8) years, 44.6% men]. Depressive symptoms were assessed at baseline and after 4 years of follow‐up using the eight‐item center for epidemiological studies—depression scale (CES‐D).Results:Approximately 26.3% (N = 1,025) of the sample were categorized as obese at baseline. Obesity at baseline was associated with elevated levels of depressive symptoms at follow‐up (P < 0.001), in analyses that adjusted for depression levels at baseline and socio demographic and background variables including the prevalence of permanent illness/disability, alcohol consumption, sedentary behavior, and smoking. In addition, C‐reactive protein (CRP) concentrations at baseline were independently associated with CES‐D depression scores at follow‐up (P = 0.008) in fully adjusted analyses. Subsequent mediation analyses revealed that CRP levels explained ∼20% of the obesity‐related longitudinal change in depression scores. Conclusion:These data suggest that chronic inflammation may be a key determinant of depressive symptoms in obesity.

AB - Objective: Obesity has been shown to produce a state of systematic low‐grade inflammation that may have detrimental neuropsychiatric effects.Design and Methods:Longitudinal associations between obesity, inflammation, and depressive symptoms amongst a cohort of older English adults over 4 years of follow‐up were examined. Participants were 3,891 obese and non obese people drawn from the English longitudinal study of ageing (ELSA) [aged 64.9 (SD = 8.8) years, 44.6% men]. Depressive symptoms were assessed at baseline and after 4 years of follow‐up using the eight‐item center for epidemiological studies—depression scale (CES‐D).Results:Approximately 26.3% (N = 1,025) of the sample were categorized as obese at baseline. Obesity at baseline was associated with elevated levels of depressive symptoms at follow‐up (P < 0.001), in analyses that adjusted for depression levels at baseline and socio demographic and background variables including the prevalence of permanent illness/disability, alcohol consumption, sedentary behavior, and smoking. In addition, C‐reactive protein (CRP) concentrations at baseline were independently associated with CES‐D depression scores at follow‐up (P = 0.008) in fully adjusted analyses. Subsequent mediation analyses revealed that CRP levels explained ∼20% of the obesity‐related longitudinal change in depression scores. Conclusion:These data suggest that chronic inflammation may be a key determinant of depressive symptoms in obesity.

KW - Obesity

KW - Depression

U2 - 10.1002/oby.20051

DO - 10.1002/oby.20051

M3 - Article

VL - 21

SP - 248

EP - 250

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 2

ER -