The relevance of heat shock regulation in fungal pathogens of humans

Alistair James Petersen Brown, Michelle Leach, Susan Melanie Nicholls

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.
Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalVirulence
Volume1
Issue number4
DOIs
Publication statusPublished - Jul 2010

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Keywords

  • heat shock response
  • Hsf1
  • Hsp90
  • transcriptional regulation
  • fungal pathogenesis
  • fungal morphogenesis

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