The response of plasma interleukin-6 and its soluble receptors to exercise in the cold in humans

Stephen Patterson, Suzanne Reid, Stuart Robert Gray, Myra Nimmo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, we wished to determine whether the changes in metabolism observed during exercise in the cold are associated with changes in interleukin-6 (IL-6) and/or its soluble receptors. Eight healthy male participants performed 1 h of cycling exercise at 70% VO2max in a control (20 degrees C) and cold (0 degrees C) environment. Plasma concentrations of IL-6, soluble IL-6 receptor (sIL-6R), and sgp130 were measured before exercise, at 30 and 60 min of exercise, and 60 min after exercise. Substrate oxidation was estimated through measures of pulmonary gas exchange recorded between 50 and 55 min of cycling. Exercise in the cold resulted in an increase (P <0.05) in carbohydrate oxidation (mean 2.58 g.min(-1), s = 0.49 at 20 degrees C vs. 2.85 g.min(-1), s = 0.58 at 0 degrees C) and a decrease (P <0.05) in fat oxidation (0.55 g.min(-1), s = 0.17 at 20 degrees C vs. 0.38 g.min(-1), s = 0.16 at 0 degrees C) compared with the control trial. Interleukin-6 concentrations were elevated (P <0.05) after 60 min of exercise in both the cold and control trials, with no differences between trials at any instant. Neither sIL-6R nor sgp130 was affected by exercise or the environment. The alterations in carbohydrate and fat utilization during 1 h of exercise in the cold are not paralleled by changes in plasma concentrations of IL-6 or its soluble receptors.
Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalJournal of Sports Sciences
Volume26
Issue number9
Early online date16 Jun 2008
DOIs
Publication statusPublished - 1 Jul 2008

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Interleukin-6
Exercise
Cytokine Receptor gp130
Interleukin-6 Receptors
Fats
Carbohydrates
Pulmonary Gas Exchange
Healthy Volunteers

Keywords

  • adult
  • analysis of variance
  • carbohydrate metabolism
  • cold temperature
  • enzyme-linked immunosorbent assay
  • exercise
  • fats
  • humans
  • interleukin-6
  • male
  • receptors, interleukin-6
  • Carbohydrate
  • cold environment
  • fat
  • interleukin-6

Cite this

The response of plasma interleukin-6 and its soluble receptors to exercise in the cold in humans. / Patterson, Stephen; Reid, Suzanne; Gray, Stuart Robert; Nimmo, Myra.

In: Journal of Sports Sciences, Vol. 26, No. 9, 01.07.2008, p. 927-933.

Research output: Contribution to journalArticle

Patterson, Stephen ; Reid, Suzanne ; Gray, Stuart Robert ; Nimmo, Myra. / The response of plasma interleukin-6 and its soluble receptors to exercise in the cold in humans. In: Journal of Sports Sciences. 2008 ; Vol. 26, No. 9. pp. 927-933.
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AB - In this study, we wished to determine whether the changes in metabolism observed during exercise in the cold are associated with changes in interleukin-6 (IL-6) and/or its soluble receptors. Eight healthy male participants performed 1 h of cycling exercise at 70% VO2max in a control (20 degrees C) and cold (0 degrees C) environment. Plasma concentrations of IL-6, soluble IL-6 receptor (sIL-6R), and sgp130 were measured before exercise, at 30 and 60 min of exercise, and 60 min after exercise. Substrate oxidation was estimated through measures of pulmonary gas exchange recorded between 50 and 55 min of cycling. Exercise in the cold resulted in an increase (P <0.05) in carbohydrate oxidation (mean 2.58 g.min(-1), s = 0.49 at 20 degrees C vs. 2.85 g.min(-1), s = 0.58 at 0 degrees C) and a decrease (P <0.05) in fat oxidation (0.55 g.min(-1), s = 0.17 at 20 degrees C vs. 0.38 g.min(-1), s = 0.16 at 0 degrees C) compared with the control trial. Interleukin-6 concentrations were elevated (P <0.05) after 60 min of exercise in both the cold and control trials, with no differences between trials at any instant. Neither sIL-6R nor sgp130 was affected by exercise or the environment. The alterations in carbohydrate and fat utilization during 1 h of exercise in the cold are not paralleled by changes in plasma concentrations of IL-6 or its soluble receptors.

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