The Role of Aeroallergen Sensitization Testing in Asthma Management

Thomas B Casale* (Corresponding Author), Soren Pedersen, Pablo Rodriguez Del Rio, Andrew H Liu, Pascal Demoly, David Price

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Asthma is a global disease affecting almost 400 million people. Simultaneously, the overall burden of allergies is increasing. Although allergies are frequent and commonly recognized triggers of asthma severity and exacerbations, the majority of patients with asthma are not investigated for their underlying aeroallergen sensitizations, despite the potentially preventable consequences and therapeutic options. This review summarizes the current state of aeroallergen sensitization testing for people with asthma. We describe who should be tested and why, how testing can be used to optimize asthma management, list barriers to implementation of effective asthma management strategies, and make recommendations for improving asthma/allergy management by aeroallergen testing. Establishing a diagnosis of asthma and determining whether there is an allergic component is fundamental to an effective treatment plan. Moreover, moving from severity-based to phenotype-based asthma care can improve the care of asthma and allergic diseases. Timely diagnosis of aeroallergen sensitizations forms the basis for individualized treatment plans, which may include allergen remediation strategies when appropriate, and allergen immunotherapy, the only immunomodulating therapy for allergic asthma. Finally, the advent of biologics will expand the number of patients who can benefit from treatment, with decreased symptoms and disease remission a possibility for the first time.

Original languageEnglish
Pages (from-to)2526-2532
Number of pages7
JournalThe journal of allergy and clinical immunology. In practice
Volume8
Issue number8
Early online date17 Jul 2020
DOIs
Publication statusPublished - Sep 2020

Keywords

  • allergy
  • asthams
  • sensitization
  • specific IgE
  • component resolved diagnostics
  • Allergy
  • Component resolved diagnostics
  • Specific IgE
  • Sensitization
  • Asthma
  • TRIGGERS
  • GUIDELINES
  • PHENOTYPES
  • CHILDREN
  • PRIMARY-CARE
  • ALLERGY

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