The role of annexins in tumour development and progression

S. Mussunoor, G. I. Murray

Research output: Contribution to journalLiterature review

189 Citations (Scopus)

Abstract

The annexins are a super-family of closely related calcium and membrane-binding proteins. They have a diverse range of cellular functions that include vesicle trafficking, cell division, apoptosis, calcium signalling and growth regulation. Many studies have shown the annexins to be among the genes whose expression are consistently differentially altered in neoplasia. Some annexins show increased expression in specific types of tumours, while others show loss of expression. Mechanistic studies relating the changes in annexin expression to tumour cell function, particularly tumour invasion and metastasis, angiogenesis and drug resistance, are now also emerging. Changes in the expression of individual annexins are associated with particular types of tumour and hence the annexins may also be useful biomarkers in the clinic. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)131-140
Number of pages10
JournalThe Journal of pathology
Volume216
Issue number2
Early online date14 Jul 2008
DOIs
Publication statusPublished - Oct 2008

Keywords

  • annexin
  • biomarker
  • expression
  • gene
  • immunohistochemistry
  • neoplasia
  • tumour
  • prostatic intraepithelialneoplasia
  • differential gene-expression
  • renal-cell carcinoma
  • breast-cancer
  • hepatocellular-carcinoma
  • protein expression
  • poor-prognosis
  • tissue microarray
  • II overexpression
  • colorectal-cancer

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