The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper

Christopher Gillberg; Elisabeth Fernell; Eva Kočovská; Helen Minnis; Thomas Bourgeron; Lucy Thompson; Clare S Allely

doi:10.1002/aur.1777

The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper

Christopher Gillberg, Elisabeth Fernell, Eva Kočovská, Helen Minnis, Thomas Bourgeron, Lucy Thompson, Clare S Allely

Research output: Contribution to journal › Review article › peer-review

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Abstract

Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the "autisms" [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as "steroid metabolism" and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. Autism Res 2017. © 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. Autism Res 2017, 10: 1022-1044. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	1022-1044
Number of pages	23
Journal	Autism Research
Volume	10
Issue number	6
Early online date	12 Apr 2017
DOIs	https://doi.org/10.1002/aur.1777
Publication status	Published - Jun 2017

Keywords

Autism Spectrum Disorder/metabolism
Cholesterol/metabolism
Estrogens/metabolism
Hormones/metabolism
Humans
Hydrocortisone/metabolism
Progesterone/metabolism
Testosterone/metabolism
Vitamin D/metabolism

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© 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Final published version, 232 KBLicence: CC BY

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The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders : A hypothesis paper. / Gillberg, Christopher; Fernell, Elisabeth; Kočovská, Eva; Minnis, Helen; Bourgeron, Thomas; Thompson, Lucy; Allely, Clare S.

In: Autism Research, Vol. 10, No. 6, 06.2017, p. 1022-1044.

Research output: Contribution to journal › Review article › peer-review

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