The role of cytochrome P450 in tumour development and progression and its potential in therapy

Research output: Contribution to journalLiterature review

84 Citations (Scopus)

Abstract

The cytochromes P450 (P450) are a large group of constitutive and inducible haem-containing enzymes, which have a central role in the oxidative metabolism of a diverse range of xenobiotics. Many P450 substrates are carcinogenic, while other substrates are anti-cancer drugs; the P450s thus have various potentially important roles in tumour biology. Several P450 genes are polymorphic and are associated with the increased risk of cancer development in specific tissues. Individual P450s, especially CYP1B1, are overexpressed in different types of tumours. The increased expression of P450s in tumours is highly significant and is important for understanding tumour development and progression. The tumour-specific expression of P450 provides the basis for the development of novel diagnostic and therapeutic strategies. Copyright (C) 2000 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)419-426
Number of pages8
JournalThe Journal of pathology
Volume192
Publication statusPublished - 2000

Keywords

  • cytochrome P450
  • breast cancer
  • colon cancer
  • immunohistochemistry
  • liver
  • tumour
  • XENOBIOTIC-METABOLIZING ENZYMES
  • HYDROCARBON HYDROXYLASE-ACTIVITY
  • GLUTATHIONE S-TRANSFERASES
  • HUMAN MAMMARY-TUMORS
  • BREAST-CANCER
  • LUNG-CANCER
  • IMMUNOHISTOCHEMICAL LOCALIZATION
  • EPOXIDE HYDROLASE
  • HUMAN-COLON
  • PULMONARY CARCINOMAS

Cite this

The role of cytochrome P450 in tumour development and progression and its potential in therapy. / Murray, G I .

In: The Journal of pathology, Vol. 192, 2000, p. 419-426.

Research output: Contribution to journalLiterature review

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abstract = "The cytochromes P450 (P450) are a large group of constitutive and inducible haem-containing enzymes, which have a central role in the oxidative metabolism of a diverse range of xenobiotics. Many P450 substrates are carcinogenic, while other substrates are anti-cancer drugs; the P450s thus have various potentially important roles in tumour biology. Several P450 genes are polymorphic and are associated with the increased risk of cancer development in specific tissues. Individual P450s, especially CYP1B1, are overexpressed in different types of tumours. The increased expression of P450s in tumours is highly significant and is important for understanding tumour development and progression. The tumour-specific expression of P450 provides the basis for the development of novel diagnostic and therapeutic strategies. Copyright (C) 2000 John Wiley & Sons, Ltd.",
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N2 - The cytochromes P450 (P450) are a large group of constitutive and inducible haem-containing enzymes, which have a central role in the oxidative metabolism of a diverse range of xenobiotics. Many P450 substrates are carcinogenic, while other substrates are anti-cancer drugs; the P450s thus have various potentially important roles in tumour biology. Several P450 genes are polymorphic and are associated with the increased risk of cancer development in specific tissues. Individual P450s, especially CYP1B1, are overexpressed in different types of tumours. The increased expression of P450s in tumours is highly significant and is important for understanding tumour development and progression. The tumour-specific expression of P450 provides the basis for the development of novel diagnostic and therapeutic strategies. Copyright (C) 2000 John Wiley & Sons, Ltd.

AB - The cytochromes P450 (P450) are a large group of constitutive and inducible haem-containing enzymes, which have a central role in the oxidative metabolism of a diverse range of xenobiotics. Many P450 substrates are carcinogenic, while other substrates are anti-cancer drugs; the P450s thus have various potentially important roles in tumour biology. Several P450 genes are polymorphic and are associated with the increased risk of cancer development in specific tissues. Individual P450s, especially CYP1B1, are overexpressed in different types of tumours. The increased expression of P450s in tumours is highly significant and is important for understanding tumour development and progression. The tumour-specific expression of P450 provides the basis for the development of novel diagnostic and therapeutic strategies. Copyright (C) 2000 John Wiley & Sons, Ltd.

KW - cytochrome P450

KW - breast cancer

KW - colon cancer

KW - immunohistochemistry

KW - liver

KW - tumour

KW - XENOBIOTIC-METABOLIZING ENZYMES

KW - HYDROCARBON HYDROXYLASE-ACTIVITY

KW - GLUTATHIONE S-TRANSFERASES

KW - HUMAN MAMMARY-TUMORS

KW - BREAST-CANCER

KW - LUNG-CANCER

KW - IMMUNOHISTOCHEMICAL LOCALIZATION

KW - EPOXIDE HYDROLASE

KW - HUMAN-COLON

KW - PULMONARY CARCINOMAS

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EP - 426

JO - The Journal of pathology

JF - The Journal of pathology

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