The role of Dectin-1 in antifungal immunity

Jurgen Herre, Janet Anne Willment, Siamon Gordon, Gordon Douglas Brown

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83 Citations (Scopus)

Abstract

beta-Glucans are structural components of fungal cell walls, which have a stimulatory effect on the immune system. Although a number of receptors for these carbohydrates have been proposed, the recently identified C-type lectin-like receptor, Dectin-1, appears to play a central role. Dectin-1 is expressed on phagocytic cells, including macrophages and neutrophils, and mediates both the internalization and cellular responses to beta-glucan, through unique mechanisms. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule, although its function in these responses is less clear. This review will highlight the current knowledge of Dectin-1 and its potential role in antifungal immunity, as well as deficiencies in our understanding.
Original languageEnglish
Pages (from-to)193-203
Number of pages11
JournalCritical Reviews in Immunology
Volume24
Issue number3
DOIs
Publication statusPublished - 2004

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Keywords

  • animals
  • fungi
  • gene expression
  • humans
  • Inflammation
  • membrane proteins
  • biological models
  • myeloid cells
  • nerve tissue proteins
  • phagocytosis
  • receptors, immunologic
  • T-lymphocytes
  • beta-glucans
  • toll-like receptor
  • pattern recognition
  • innate immunity
  • macrophage
  • expression
  • pathway
  • system
  • cells
  • identification

Cite this

Herre, J., Willment, J. A., Gordon, S., & Brown, G. D. (2004). The role of Dectin-1 in antifungal immunity. Critical Reviews in Immunology, 24(3), 193-203. https://doi.org/10.1615/CritRevImmunol.v24.i3.30