Abstract
Although Candida glabrata is an important pathogenic Candida species, relatively little is known about its innate immune recognition. Here we explore the potential role of Dectin-2 for host defense against C. glabrata. Dectin-2-deficient (Dectin-2-/-) mice were found to be more susceptible to C. glabrata infections, showing a defective fungal clearance in kidneys, but not in the liver. The increased susceptibility to infection was accompanied by lower production of T helper 1 (Th1) and Th17-derived cytokines by splenocytes of Dectin-2-/- mice, while macrophage-derived cytokines were less affected. These defects were associated with a moderate, yet significant, decreased phagocytosis of the fungus by the Dectin-2-/- macrophages and neutrophils. Neutrophils of Dectin-2-/- mice also displayed a lower production of reactive oxygen species (ROS) upon challenge with opsonized C. glabrata or C. albicans. This study suggests that Dectin-2 is important in host defense against C. glabrata and provides new insights in the host defense mechanisms against this important fungal pathogen.
Original language | English |
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Pages (from-to) | 1064-1073 |
Number of pages | 10 |
Journal | Infection and Immunity |
Volume | 82 |
Issue number | 3 |
Early online date | 16 Dec 2013 |
DOIs | |
Publication status | Published - Mar 2014 |
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Microscopy and Histology
Debbie Wilkinson (Manager) & Gillian Milne (Manager)
Medical SciencesResearch Facilities: Facility