The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Domenico Sergi, Hakim Boulestin, Fiona M Campbell, Lynda M Williams* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Advanced glycation end products (AGEs) are a heterogeneous group of molecules produced, non‐enzymatically, from the interaction between reducing sugars and the free amino groups of proteins, nucleic acids, and lipids. AGEs are formed as a normal consequence of metabolism but can also be absorbed from the diet. They have been widely implicated in the complications of diabetes affecting cardiovascular health, the nervous system, eyes, and kidneys. Increased levels of AGEs are also detrimental to metabolic health and may contribute to the metabolic abnormalities induced by the Western diet, which is high in processed foods and represents a significant source of AGEs. While increased AGE levels are a consequence of diabetic hyperglycaemia, AGEs themselves activate signaling pathways, which compromise insulin signaling and pancreatic β‐cell function, thus, contributing to the development of type 2 diabetes mellitus (T2DM). Furthermore, AGEs may also contribute to the obesogenic effects of the Western diet by promoting hypothalamic inflammation and disrupting the central control of energy balance. Here, the role of dietary AGEs in metabolic dysfunction is reviewed with a focus on the mechanisms underpinning their detrimental role in insulin resistance, pancreatic β‐cell dysfunction, hypothalamic control of energy balance, and the pathogenesis of T2DM and obesity.

Original languageEnglish
Article number1900934
JournalMolecular Nutrition & Food Research
Early online date20 Apr 2020
DOIs
Publication statusE-pub ahead of print - 20 Apr 2020

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Keywords

  • Western diet
  • advanced glycation end products
  • inflammation
  • metabolic dysfunction
  • processed foods
  • OXIDATIVE STRESS
  • CARBOXYMETHYL-LYSINE
  • TRANSEPITHELIAL FLUX
  • ENDPRODUCTS AGES
  • DIABETES-MELLITUS
  • SKELETAL-MUSCLE
  • INSULIN-RESISTANCE
  • CACO-2 CELL MONOLAYERS
  • POTENTIAL ROLE
  • TRANSGENIC MICE

ASJC Scopus subject areas

  • Food Science
  • Biotechnology

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