The role of dynamin in the assembly and function of podosomes and invadopodia

Mark A McNiven, Massimiliano Baldassarre, Roberto Buccione

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Cells make contact with the extracellular matrix (ECM) through extensions of the plasma membrane; these range from irregular dynamic structures, e.g. lamellipodia, ruffles and pseudopodia, to more localized and highly defined protrusions, e.g. podosomes and invadopodia. Both might be instruments through which cells sample the immediate extracellular environment and maintain polarized activities such as chemotaxis and focal degradation of the matrix. Podosomes are expressed in cells of the monocytic lineage, and most studies point to a role for podosomes in adhesion/motility. Invadopodia are prominent in certain aggressive cancer cells (or transformed cells) and appear to be directly responsible for focal ECM degradation. Recent studies have revived interest in these structures in terms of the actin regulation machinery. Within this framework, the atypical GTP-binding protein dynamin, a central modulator of protrusive events, has been associated to podosome and invadopodia structure and function. Here, we specifically discuss the role played by dynamin in controlling the activities and function of these structures.

Original languageEnglish
Pages (from-to)1944-53
Number of pages10
JournalFrontiers in Bioscience
Volume9
Publication statusPublished - 1 May 2004

Fingerprint

Dynamins
Degradation
Cell membranes
Pseudopodia
GTP-Binding Proteins
Modulators
Machinery
Actins
Adhesion
Extracellular Matrix
Cells
Cell Lineage
Chemotaxis
Podosomes
Cell Membrane

Keywords

  • Animals
  • Cell Adhesion
  • Cell Membrane Structures
  • Cell Movement
  • Dynamins
  • Humans
  • Microfilament Proteins
  • Monocytes
  • Neoplasm Invasiveness
  • Neoplasms
  • Osteoclasts

Cite this

The role of dynamin in the assembly and function of podosomes and invadopodia. / McNiven, Mark A; Baldassarre, Massimiliano; Buccione, Roberto.

In: Frontiers in Bioscience, Vol. 9, 01.05.2004, p. 1944-53.

Research output: Contribution to journalArticle

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