The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans: implications in virulence

Carmen Herrero De Dios, Elvira Roman, Rebeca Alonso Monge, Jesus Pla

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In recent years, Mitogen-Activated Protein Kinase (MAPK) pathways have emerged as major regulators of cellular physiology. In the fungal pathogen Candida albicans, three different MAPK pathways have been characterized in the last years. The HOG pathway is mainly a stress response pathway that is activated in response to osmotic and oxidative stress and also participates regulating other pathways. The SVG pathway (or mediated by the Cek1 MAPK) is involved in cell wall formation under vegetative and filamentous growth, while the Mkc1-mediated pathway is involved in cell wall integrity. Oxidative stress is one of the types of stress that every fungal cell has to face during colonization of the host, where the cell encounters both hypoxia niches (i.e. gut) and high concentrations of reactive oxygen species (upon challenge with immune cells). Two pathways have been shown to be activated in response to oxidative stress: the HOG pathway and the Mkc1-mediated pathway while the third, the Cek1 pathway is deactivated. The timing, kinetics, stimuli and functional responses generated upon oxidative stress differ among them; however, they have essential functional consequences that severely influence pathogenesis. MAPK pathways are, therefore, valuable targets to be explored in antifungal research.
Original languageEnglish
Pages (from-to)693-703
Number of pages11
JournalCurrent Protein & Peptide Science
Volume11
Issue number8
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Signal transduction
Oxidative stress
Candida
Pathogens
Mitogen-Activated Protein Kinases
Candida albicans
Virulence
Signal Transduction
Oxidative Stress
Cell Wall
Cells
Osmotic Pressure
Physiology
Reactive Oxygen Species
Kinetics
Growth
Research

Keywords

  • Candida albicans
  • MAP kinase
  • oxidative stress
  • virulence
  • pathogenesis

Cite this

The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans : implications in virulence. / Herrero De Dios, Carmen ; Roman, Elvira; Alonso Monge, Rebeca; Pla, Jesus.

In: Current Protein & Peptide Science, Vol. 11, No. 8, 12.2010, p. 693-703.

Research output: Contribution to journalArticle

Herrero De Dios, Carmen ; Roman, Elvira ; Alonso Monge, Rebeca ; Pla, Jesus. / The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans : implications in virulence. In: Current Protein & Peptide Science. 2010 ; Vol. 11, No. 8. pp. 693-703.
@article{10af7ac4e2d740d894730c8f55bd43ca,
title = "The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans: implications in virulence",
abstract = "In recent years, Mitogen-Activated Protein Kinase (MAPK) pathways have emerged as major regulators of cellular physiology. In the fungal pathogen Candida albicans, three different MAPK pathways have been characterized in the last years. The HOG pathway is mainly a stress response pathway that is activated in response to osmotic and oxidative stress and also participates regulating other pathways. The SVG pathway (or mediated by the Cek1 MAPK) is involved in cell wall formation under vegetative and filamentous growth, while the Mkc1-mediated pathway is involved in cell wall integrity. Oxidative stress is one of the types of stress that every fungal cell has to face during colonization of the host, where the cell encounters both hypoxia niches (i.e. gut) and high concentrations of reactive oxygen species (upon challenge with immune cells). Two pathways have been shown to be activated in response to oxidative stress: the HOG pathway and the Mkc1-mediated pathway while the third, the Cek1 pathway is deactivated. The timing, kinetics, stimuli and functional responses generated upon oxidative stress differ among them; however, they have essential functional consequences that severely influence pathogenesis. MAPK pathways are, therefore, valuable targets to be explored in antifungal research.",
keywords = "Candida albicans, MAP kinase, oxidative stress, virulence, pathogenesis",
author = "{Herrero De Dios}, Carmen and Elvira Roman and {Alonso Monge}, Rebeca and Jesus Pla",
year = "2010",
month = "12",
doi = "10.2174/138920310794557655",
language = "English",
volume = "11",
pages = "693--703",
journal = "Current Protein & Peptide Science",
issn = "1389-2037",
publisher = "Bentham Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans

T2 - implications in virulence

AU - Herrero De Dios, Carmen

AU - Roman, Elvira

AU - Alonso Monge, Rebeca

AU - Pla, Jesus

PY - 2010/12

Y1 - 2010/12

N2 - In recent years, Mitogen-Activated Protein Kinase (MAPK) pathways have emerged as major regulators of cellular physiology. In the fungal pathogen Candida albicans, three different MAPK pathways have been characterized in the last years. The HOG pathway is mainly a stress response pathway that is activated in response to osmotic and oxidative stress and also participates regulating other pathways. The SVG pathway (or mediated by the Cek1 MAPK) is involved in cell wall formation under vegetative and filamentous growth, while the Mkc1-mediated pathway is involved in cell wall integrity. Oxidative stress is one of the types of stress that every fungal cell has to face during colonization of the host, where the cell encounters both hypoxia niches (i.e. gut) and high concentrations of reactive oxygen species (upon challenge with immune cells). Two pathways have been shown to be activated in response to oxidative stress: the HOG pathway and the Mkc1-mediated pathway while the third, the Cek1 pathway is deactivated. The timing, kinetics, stimuli and functional responses generated upon oxidative stress differ among them; however, they have essential functional consequences that severely influence pathogenesis. MAPK pathways are, therefore, valuable targets to be explored in antifungal research.

AB - In recent years, Mitogen-Activated Protein Kinase (MAPK) pathways have emerged as major regulators of cellular physiology. In the fungal pathogen Candida albicans, three different MAPK pathways have been characterized in the last years. The HOG pathway is mainly a stress response pathway that is activated in response to osmotic and oxidative stress and also participates regulating other pathways. The SVG pathway (or mediated by the Cek1 MAPK) is involved in cell wall formation under vegetative and filamentous growth, while the Mkc1-mediated pathway is involved in cell wall integrity. Oxidative stress is one of the types of stress that every fungal cell has to face during colonization of the host, where the cell encounters both hypoxia niches (i.e. gut) and high concentrations of reactive oxygen species (upon challenge with immune cells). Two pathways have been shown to be activated in response to oxidative stress: the HOG pathway and the Mkc1-mediated pathway while the third, the Cek1 pathway is deactivated. The timing, kinetics, stimuli and functional responses generated upon oxidative stress differ among them; however, they have essential functional consequences that severely influence pathogenesis. MAPK pathways are, therefore, valuable targets to be explored in antifungal research.

KW - Candida albicans

KW - MAP kinase

KW - oxidative stress

KW - virulence

KW - pathogenesis

U2 - 10.2174/138920310794557655

DO - 10.2174/138920310794557655

M3 - Article

VL - 11

SP - 693

EP - 703

JO - Current Protein & Peptide Science

JF - Current Protein & Peptide Science

SN - 1389-2037

IS - 8

ER -