The Role of Platelets in Fibrinolysis

Nicola J. Mutch*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter reviews the complex manner by which platelets interact and regulate aspects of the fibrinolytic system in both a positive and negative manner. The key mechanisms are: (1) the secretion of a number of key proteins and molecules during platelet activation that influence the fibrinolytic system, the most noteworthy of which, platelet PAI-1, correlates directly with the lysability of thrombi; (2) the platelet membrane provides a surface to support plasminogen activation via binding of plasminogen, plasminogen activators, and proteins of the contact pathway; and (3) platelets modify clot structure, with dense areas of fibrin forming around platelet masses, which hinders movement of the lysis front through the clot. The net effect of these reactions is difficult to appraise and is most likely related to platelet concentration and proximity to fibrin and the endothelium, as well as the expression and binding of proteins to the platelet surface.
Original languageEnglish
Title of host publicationPlatelets
EditorsAlan Michelson
PublisherElsevier Inc
Pages469-485
Number of pages17
Edition3
ISBN (Electronic)9780123878380
ISBN (Print)9780123878373
DOIs
Publication statusPublished - 2013

Keywords

  • fibrinolysis
  • hemostasis
  • plasminogen
  • plasmin
  • tPA
  • uPA
  • fibrin
  • α2AP
  • TAFI
  • PAI-1

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