The role of selenium in mercury toxicity – current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices

Zuzana Gajdosechova, Zoltan Mester, Jörg Feldmann, Eva M. Krupp

Research output: Contribution to journalArticle

5 Citations (Scopus)
5 Downloads (Pure)

Abstract

Abstract Mercury forms potent toxic compounds, which cause irreversible damage to the central nervous system, while selenium, if present in an adequate concentration, is an essential micronutrient needed for the regulation of metabolic processes. The interactions between mercury and selenium have been rigorously scrutinized particularly due to observed protective effects of selenium against mercury toxicity, however very few proposed mechanisms are supported by empirical data. With mercury concentrations steadily rising in the environment, this matter is of urgency, and pushes for the development of new sample preparation protocols and analytical techniques. Softer extraction methods should preserve the true chemical species, while a combination of chromatographic and direct analytical techniques enable identification and quantitation. This review summarizes the state of the art of current analytical techniques, which focus on the interactions between mercury and selenium in biological matrices and outlines the future trends that might fill major gaps in our analytical capabilities.
Original languageEnglish
Pages (from-to)95-109
Number of pages15
JournalTrends in Analytical Chemistry
Volume104
Early online date11 Dec 2017
DOIs
Publication statusPublished - Jul 2018

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Selenium
Mercury
Toxicity
Micronutrients
Poisons
Neurology

Keywords

  • mercury
  • selenium
  • bio-molecules
  • speciation
  • extraction
  • ESI-MS
  • XANES
  • chromatography
  • nanoparticles
  • isotope ratio

Cite this

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title = "The role of selenium in mercury toxicity – current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices",
abstract = "Abstract Mercury forms potent toxic compounds, which cause irreversible damage to the central nervous system, while selenium, if present in an adequate concentration, is an essential micronutrient needed for the regulation of metabolic processes. The interactions between mercury and selenium have been rigorously scrutinized particularly due to observed protective effects of selenium against mercury toxicity, however very few proposed mechanisms are supported by empirical data. With mercury concentrations steadily rising in the environment, this matter is of urgency, and pushes for the development of new sample preparation protocols and analytical techniques. Softer extraction methods should preserve the true chemical species, while a combination of chromatographic and direct analytical techniques enable identification and quantitation. This review summarizes the state of the art of current analytical techniques, which focus on the interactions between mercury and selenium in biological matrices and outlines the future trends that might fill major gaps in our analytical capabilities.",
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author = "Zuzana Gajdosechova and Zoltan Mester and J{\"o}rg Feldmann and Krupp, {Eva M.}",
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T1 - The role of selenium in mercury toxicity – current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices

AU - Gajdosechova, Zuzana

AU - Mester, Zoltan

AU - Feldmann, Jörg

AU - Krupp, Eva M.

PY - 2018/7

Y1 - 2018/7

N2 - Abstract Mercury forms potent toxic compounds, which cause irreversible damage to the central nervous system, while selenium, if present in an adequate concentration, is an essential micronutrient needed for the regulation of metabolic processes. The interactions between mercury and selenium have been rigorously scrutinized particularly due to observed protective effects of selenium against mercury toxicity, however very few proposed mechanisms are supported by empirical data. With mercury concentrations steadily rising in the environment, this matter is of urgency, and pushes for the development of new sample preparation protocols and analytical techniques. Softer extraction methods should preserve the true chemical species, while a combination of chromatographic and direct analytical techniques enable identification and quantitation. This review summarizes the state of the art of current analytical techniques, which focus on the interactions between mercury and selenium in biological matrices and outlines the future trends that might fill major gaps in our analytical capabilities.

AB - Abstract Mercury forms potent toxic compounds, which cause irreversible damage to the central nervous system, while selenium, if present in an adequate concentration, is an essential micronutrient needed for the regulation of metabolic processes. The interactions between mercury and selenium have been rigorously scrutinized particularly due to observed protective effects of selenium against mercury toxicity, however very few proposed mechanisms are supported by empirical data. With mercury concentrations steadily rising in the environment, this matter is of urgency, and pushes for the development of new sample preparation protocols and analytical techniques. Softer extraction methods should preserve the true chemical species, while a combination of chromatographic and direct analytical techniques enable identification and quantitation. This review summarizes the state of the art of current analytical techniques, which focus on the interactions between mercury and selenium in biological matrices and outlines the future trends that might fill major gaps in our analytical capabilities.

KW - mercury

KW - selenium

KW - bio-molecules

KW - speciation

KW - extraction

KW - ESI-MS

KW - XANES

KW - chromatography

KW - nanoparticles

KW - isotope ratio

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DO - 10.1016/j.trac.2017.12.005

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