The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

Rebecca A Drummond, Shinobu Saijo, Yoichiro Iwakura, Gordon D Brown

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-¿B activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.
Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalEuropean Journal of Immunology
Volume41
Issue number2
Early online date11 Jan 2011
DOIs
Publication statusPublished - Feb 2011

Fingerprint

C-Type Lectins
Immunity
Pattern Recognition Receptors
Mycoses
Adaptive Immunity
Innate Immunity
Immunotherapy
Signal Transduction
Fungi
Mortality
Therapeutics
Infection

Keywords

  • adaptor proteins, signal transducing
  • animals
  • CARD signaling adaptor proteins
  • humans
  • intracellular signaling peptides and proteins
  • lectins, C-type
  • mycoses
  • protein-tyrosine kinases
  • signal transduction

Cite this

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. / Drummond, Rebecca A; Saijo, Shinobu; Iwakura, Yoichiro; Brown, Gordon D.

In: European Journal of Immunology, Vol. 41, No. 2, 02.2011, p. 276-281.

Research output: Contribution to journalArticle

Drummond, Rebecca A ; Saijo, Shinobu ; Iwakura, Yoichiro ; Brown, Gordon D. / The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. In: European Journal of Immunology. 2011 ; Vol. 41, No. 2. pp. 276-281.
@article{84439a818c8d46d597f6275d6ce66c03,
title = "The role of Syk/CARD9 coupled C-type lectins in antifungal immunity",
abstract = "Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-¿B activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.",
keywords = "adaptor proteins, signal transducing, animals, CARD signaling adaptor proteins, humans, intracellular signaling peptides and proteins, lectins, C-type, mycoses, protein-tyrosine kinases, signal transduction",
author = "Drummond, {Rebecca A} and Shinobu Saijo and Yoichiro Iwakura and Brown, {Gordon D}",
note = "Copyright {\circledC} 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2011",
month = "2",
doi = "10.1002/eji.201041252",
language = "English",
volume = "41",
pages = "276--281",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "2",

}

TY - JOUR

T1 - The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

AU - Drummond, Rebecca A

AU - Saijo, Shinobu

AU - Iwakura, Yoichiro

AU - Brown, Gordon D

N1 - Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2011/2

Y1 - 2011/2

N2 - Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-¿B activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.

AB - Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-¿B activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.

KW - adaptor proteins, signal transducing

KW - animals

KW - CARD signaling adaptor proteins

KW - humans

KW - intracellular signaling peptides and proteins

KW - lectins, C-type

KW - mycoses

KW - protein-tyrosine kinases

KW - signal transduction

U2 - 10.1002/eji.201041252

DO - 10.1002/eji.201041252

M3 - Article

C2 - 21267996

VL - 41

SP - 276

EP - 281

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 2

ER -