The roles of heterogeneous ribonucleoproteins in tumour development and progression

Graeme Ian Murray, C. Mackay, A. Alnabulsi, C. Telfer, W. T. Melvin, Brian Carpenter, M. McKay

Research output: Contribution to journalEditorial

191 Citations (Scopus)

Abstract

The heterogeneous nuclear ribonucleoproteins (hnRNP) are a family of proteins which share common structural domains, and extensive research has shown that they have central roles in DNA repair, telomere biogenesis, cell signaling and in regulating gene expression at both transcriptional and translational levels. Through these key cellular functions, individual hnRNPs have a variety of potential roles in tumour development and progression including the inhibition of apoptosis, angiogenesis and cell invasion. The aims of this review are to provide an overview of the multi functional roles of the hnRNPs, and how such roles implicate this family as regulators of tumour development. The different stages of tumour development that are potentially regulated by the hnRNPs along with their aberrant expression profiles in tumour tissues will also be discussed. (c) 2005 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)85-100
Number of pages15
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1765
DOIs
Publication statusPublished - 2006

Keywords

  • heterogeneous nuclear ribonucleoproteins
  • structure
  • cellular function
  • neoplasm
  • tumour
  • diagnosis
  • treatment
  • gene expression
  • TRACT-BINDING-PROTEIN
  • MESSENGER-RNA STABILITY
  • LUNG-CANCER DETECTION
  • HNRNP K-PROTEIN
  • TRANSCRIPTION FACTOR CHOP
  • SQUAMOUS-CELL CARCINOMA
  • INDUCED SPLICING ARREST
  • HUMAN MYELOID-LEUKEMIA
  • AU-RICH ELEMENT
  • IN-VITRO

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