The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study

Phyo K Myint, Richard D Smith, Robert N Luben, Paul G Surtees, Nicholas W J Wainwright, Nicholas J Wareham, Sheila A Bingham, Kay-Tee Khaw

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality.

STUDY DESIGN AND SETTING: Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined.

RESULTS: One thousand and seventy deaths occurred during a total of 115,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of 1 standard deviation (0.12 point) in SF-6D was associated with a 35% increase in all-cause mortality (hazards ratio = 1.35; 95% CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths.

CONCLUSION: Poor health utility measured by the SF-6D predicted increased risk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalJournal of Clinical Epidemiology
Volume63
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • adult
  • aged
  • cardiovascular diseases
  • England
  • female
  • health status indicators
  • humans
  • male
  • middle aged
  • mortality
  • neoplasms
  • prognosis
  • prospective studies
  • quality of life
  • smoking
  • social class

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