Abstract
OBJECTIVE: To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality.
STUDY DESIGN AND SETTING: Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined.
RESULTS: One thousand and seventy deaths occurred during a total of 115,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of 1 standard deviation (0.12 point) in SF-6D was associated with a 35% increase in all-cause mortality (hazards ratio = 1.35; 95% CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths.
CONCLUSION: Poor health utility measured by the SF-6D predicted increased risk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population.
Original language | English |
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Pages (from-to) | 192-198 |
Number of pages | 7 |
Journal | Journal of Clinical Epidemiology |
Volume | 63 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2010 |
Bibliographical note
Copyright 2010 Elsevier Inc. All rights reserved.Keywords
- adult
- aged
- cardiovascular diseases
- England
- female
- health status indicators
- humans
- male
- middle aged
- mortality
- neoplasms
- prognosis
- prospective studies
- quality of life
- smoking
- social class