The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study

Phyo K Myint, Richard D Smith, Robert N Luben, Paul G Surtees, Nicholas W J Wainwright, Nicholas J Wareham, Sheila A Bingham, Kay-Tee Khaw

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality.

STUDY DESIGN AND SETTING: Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined.

RESULTS: One thousand and seventy deaths occurred during a total of 115,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of 1 standard deviation (0.12 point) in SF-6D was associated with a 35% increase in all-cause mortality (hazards ratio = 1.35; 95% CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths.

CONCLUSION: Poor health utility measured by the SF-6D predicted increased risk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalJournal of Clinical Epidemiology
Volume63
Issue number2
DOIs
Publication statusPublished - Feb 2010

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Mortality
Population
Neoplasms
Blood Pressure
Social Class
Cause of Death
Body Mass Index
Cardiovascular Diseases
Smoking
Cholesterol
Prospective Studies
Health

Keywords

  • adult
  • aged
  • cardiovascular diseases
  • England
  • female
  • health status indicators
  • humans
  • male
  • middle aged
  • mortality
  • neoplasms
  • prognosis
  • prospective studies
  • quality of life
  • smoking
  • social class

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The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study. / Myint, Phyo K; Smith, Richard D; Luben, Robert N; Surtees, Paul G; Wainwright, Nicholas W J; Wareham, Nicholas J; Bingham, Sheila A; Khaw, Kay-Tee.

In: Journal of Clinical Epidemiology, Vol. 63, No. 2, 02.2010, p. 192-198.

Research output: Contribution to journalArticle

Myint, Phyo K ; Smith, Richard D ; Luben, Robert N ; Surtees, Paul G ; Wainwright, Nicholas W J ; Wareham, Nicholas J ; Bingham, Sheila A ; Khaw, Kay-Tee. / The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study. In: Journal of Clinical Epidemiology. 2010 ; Vol. 63, No. 2. pp. 192-198.
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abstract = "OBJECTIVE: To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality.STUDY DESIGN AND SETTING: Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined.RESULTS: One thousand and seventy deaths occurred during a total of 115,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of 1 standard deviation (0.12 point) in SF-6D was associated with a 35{\%} increase in all-cause mortality (hazards ratio = 1.35; 95{\%} CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths.CONCLUSION: Poor health utility measured by the SF-6D predicted increased risk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population.",
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AU - Myint, Phyo K

AU - Smith, Richard D

AU - Luben, Robert N

AU - Surtees, Paul G

AU - Wainwright, Nicholas W J

AU - Wareham, Nicholas J

AU - Bingham, Sheila A

AU - Khaw, Kay-Tee

N1 - Copyright 2010 Elsevier Inc. All rights reserved.

PY - 2010/2

Y1 - 2010/2

N2 - OBJECTIVE: To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality.STUDY DESIGN AND SETTING: Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined.RESULTS: One thousand and seventy deaths occurred during a total of 115,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of 1 standard deviation (0.12 point) in SF-6D was associated with a 35% increase in all-cause mortality (hazards ratio = 1.35; 95% CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths.CONCLUSION: Poor health utility measured by the SF-6D predicted increased risk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population.

AB - OBJECTIVE: To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality.STUDY DESIGN AND SETTING: Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined.RESULTS: One thousand and seventy deaths occurred during a total of 115,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of 1 standard deviation (0.12 point) in SF-6D was associated with a 35% increase in all-cause mortality (hazards ratio = 1.35; 95% CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths.CONCLUSION: Poor health utility measured by the SF-6D predicted increased risk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population.

KW - adult

KW - aged

KW - cardiovascular diseases

KW - England

KW - female

KW - health status indicators

KW - humans

KW - male

KW - middle aged

KW - mortality

KW - neoplasms

KW - prognosis

KW - prospective studies

KW - quality of life

KW - smoking

KW - social class

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DO - 10.1016/j.jclinepi.2009.05.002

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VL - 63

SP - 192

EP - 198

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

SN - 0895-4356

IS - 2

ER -