The skeleton - a multi-functional complex organ

The role of key signalling pathways in osteoclast differentiation and in bone resorption

David Mellis, Cecile Itzstein, Marie Helfrich, Julie Clare Crockett

Research output: Contribution to journalLiterature review

63 Citations (Scopus)

Abstract

Osteoclasts are the specialised cells that resorb bone matrix and are important both during the growth and shaping of bones during development as well as during the process of bone remodelling that occurs throughout life to maintain a healthy skeleton. Osteoclast formation, function and survival are tightly regulated by a network of signalling pathways, many of which have been identified through the study of rare monogenic diseases, knockout mouse models and animal strains carrying naturally occurring mutations in key molecules. In this review we describe the processes of osteoclast formation, activation and function and discuss the major transcription factors and signalling pathways (including those that control the cytoskeletal rearrangements) that are important at each stage.
Original languageEnglish
Pages (from-to)131-143
Number of pages13
JournalJournal of Endocrinology
Volume211
Early online date8 Sep 2011
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Osteoclasts
Bone Resorption
Skeleton
Bone Matrix
Bone Remodeling
Bone Development
Rare Diseases
Knockout Mice
Transcription Factors
Animal Models
Mutation
Growth

Keywords

  • osteoclast
  • bone formation and resorption
  • cytoskeletal proteins
  • transcription factors
  • intracellular signalling

Cite this

The skeleton - a multi-functional complex organ : The role of key signalling pathways in osteoclast differentiation and in bone resorption. / Mellis, David; Itzstein, Cecile; Helfrich, Marie; Crockett, Julie Clare.

In: Journal of Endocrinology, Vol. 211, 11.2011, p. 131-143.

Research output: Contribution to journalLiterature review

Mellis, David ; Itzstein, Cecile ; Helfrich, Marie ; Crockett, Julie Clare. / The skeleton - a multi-functional complex organ : The role of key signalling pathways in osteoclast differentiation and in bone resorption. In: Journal of Endocrinology. 2011 ; Vol. 211. pp. 131-143.
@article{e07cdd787ea448ee9394364fbb001651,
title = "The skeleton - a multi-functional complex organ: The role of key signalling pathways in osteoclast differentiation and in bone resorption",
abstract = "Osteoclasts are the specialised cells that resorb bone matrix and are important both during the growth and shaping of bones during development as well as during the process of bone remodelling that occurs throughout life to maintain a healthy skeleton. Osteoclast formation, function and survival are tightly regulated by a network of signalling pathways, many of which have been identified through the study of rare monogenic diseases, knockout mouse models and animal strains carrying naturally occurring mutations in key molecules. In this review we describe the processes of osteoclast formation, activation and function and discuss the major transcription factors and signalling pathways (including those that control the cytoskeletal rearrangements) that are important at each stage.",
keywords = "osteoclast, bone formation and resorption, cytoskeletal proteins, transcription factors, intracellular signalling",
author = "David Mellis and Cecile Itzstein and Marie Helfrich and Crockett, {Julie Clare}",
year = "2011",
month = "11",
doi = "10.1530/JOE-11-0212",
language = "English",
volume = "211",
pages = "131--143",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "Society for Endocrinology",

}

TY - JOUR

T1 - The skeleton - a multi-functional complex organ

T2 - The role of key signalling pathways in osteoclast differentiation and in bone resorption

AU - Mellis, David

AU - Itzstein, Cecile

AU - Helfrich, Marie

AU - Crockett, Julie Clare

PY - 2011/11

Y1 - 2011/11

N2 - Osteoclasts are the specialised cells that resorb bone matrix and are important both during the growth and shaping of bones during development as well as during the process of bone remodelling that occurs throughout life to maintain a healthy skeleton. Osteoclast formation, function and survival are tightly regulated by a network of signalling pathways, many of which have been identified through the study of rare monogenic diseases, knockout mouse models and animal strains carrying naturally occurring mutations in key molecules. In this review we describe the processes of osteoclast formation, activation and function and discuss the major transcription factors and signalling pathways (including those that control the cytoskeletal rearrangements) that are important at each stage.

AB - Osteoclasts are the specialised cells that resorb bone matrix and are important both during the growth and shaping of bones during development as well as during the process of bone remodelling that occurs throughout life to maintain a healthy skeleton. Osteoclast formation, function and survival are tightly regulated by a network of signalling pathways, many of which have been identified through the study of rare monogenic diseases, knockout mouse models and animal strains carrying naturally occurring mutations in key molecules. In this review we describe the processes of osteoclast formation, activation and function and discuss the major transcription factors and signalling pathways (including those that control the cytoskeletal rearrangements) that are important at each stage.

KW - osteoclast

KW - bone formation and resorption

KW - cytoskeletal proteins

KW - transcription factors

KW - intracellular signalling

U2 - 10.1530/JOE-11-0212

DO - 10.1530/JOE-11-0212

M3 - Literature review

VL - 211

SP - 131

EP - 143

JO - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

ER -