Abstract
Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis. It also has an important role in tumor invasion and metastasis. This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule.
| Original language | English |
|---|---|
| Pages (from-to) | 149-166 |
| Number of pages | 17 |
| Journal | Critical Reviews in Biochemistry and Molecular Biology |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 |
Keywords
- HUMAN OSTEOARTHRITIC CARTILAGE
- HUMAN COLLAGENASE-3 MMP-13
- SQUAMOUS-CELL CARCINOMAS
- ACTIVATED PROTEIN-KINASE
- FIBROBLAST-GROWTH-FACTOR
- HEMOPEXIN-LIKE DOMAIN
- N-TERMINAL KINASE
- GENE-EXPRESSION
- TUMOR INVASION
- MESSENGER-RNA
Cite this
The structure, regulation, and function of human matrix metalloproteinase-13. / Leeman, M. F.; Curran, Stephanie; Murray, Graeme Ian.
In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 37, No. 3, 2002, p. 149-166.Research output: Contribution to journal › Editorial
}
TY - JOUR
T1 - The structure, regulation, and function of human matrix metalloproteinase-13
AU - Leeman, M. F.
AU - Curran, Stephanie
AU - Murray, Graeme Ian
PY - 2002
Y1 - 2002
N2 - Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis. It also has an important role in tumor invasion and metastasis. This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule.
AB - Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis. It also has an important role in tumor invasion and metastasis. This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule.
KW - HUMAN OSTEOARTHRITIC CARTILAGE
KW - HUMAN COLLAGENASE-3 MMP-13
KW - SQUAMOUS-CELL CARCINOMAS
KW - ACTIVATED PROTEIN-KINASE
KW - FIBROBLAST-GROWTH-FACTOR
KW - HEMOPEXIN-LIKE DOMAIN
KW - N-TERMINAL KINASE
KW - GENE-EXPRESSION
KW - TUMOR INVASION
KW - MESSENGER-RNA
U2 - 10.1080/10409230290771483
DO - 10.1080/10409230290771483
M3 - Editorial
VL - 37
SP - 149
EP - 166
JO - Critical Reviews in Biochemistry and Molecular Biology
JF - Critical Reviews in Biochemistry and Molecular Biology
SN - 1040-9238
IS - 3
ER -