The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

Mohlopheni J Marakalala, Reto Guler, Lungile Matika, Graeme Murray, Muazzam Jacobs, Frank Brombacher, Antonio Gigliotti Rothfuchs, Alan Sher, Gordon D Brown

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29 Citations (Scopus)

Abstract

There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.
Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalMicrobes and Infection
Volume13
Issue number2
Early online date27 Oct 2010
DOIs
Publication statusPublished - Feb 2011

Keywords

  • adaptor proteins, signal transducing
  • animals
  • cytokines
  • female
  • immunity, innate
  • membrane proteins
  • mice
  • mice, knockout
  • Mycobacterium tuberculosis
  • nerve tissue proteins
  • nuclear proteins
  • tuberculosis, pulmonary

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  • Cite this

    Marakalala, M. J., Guler, R., Matika, L., Murray, G., Jacobs, M., Brombacher, F., Rothfuchs, A. G., Sher, A., & Brown, G. D. (2011). The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes and Infection, 13(2), 198-201. https://doi.org/10.1016/j.micinf.2010.10.013