The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

Mohlopheni J Marakalala, Reto Guler, Lungile Matika, Graeme Murray, Muazzam Jacobs, Frank Brombacher, Antonio Gigliotti Rothfuchs, Alan Sher, Gordon D Brown

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.
Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalMicrobes and Infection
Volume13
Issue number2
Early online date27 Oct 2010
DOIs
Publication statusPublished - Feb 2011

Keywords

  • adaptor proteins, signal transducing
  • animals
  • cytokines
  • female
  • immunity, innate
  • membrane proteins
  • mice
  • mice, knockout
  • Mycobacterium tuberculosis
  • nerve tissue proteins
  • nuclear proteins
  • tuberculosis, pulmonary

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