The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

Mohlopheni J Marakalala, Reto Guler, Lungile Matika, Graeme Murray, Muazzam Jacobs, Frank Brombacher, Antonio Gigliotti Rothfuchs, Alan Sher, Gordon D Brown

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.
Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalMicrobes and Infection
Volume13
Issue number2
Early online date27 Oct 2010
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Mycobacterium tuberculosis
Pattern Recognition Receptors
Lung
Mycobacterium Infections
Aerosols
Bacillus
Pathology
Cytokines
dectin 1
Infection

Keywords

  • adaptor proteins, signal transducing
  • animals
  • cytokines
  • female
  • immunity, innate
  • membrane proteins
  • mice
  • mice, knockout
  • Mycobacterium tuberculosis
  • nerve tissue proteins
  • nuclear proteins
  • tuberculosis, pulmonary

Cite this

Marakalala, M. J., Guler, R., Matika, L., Murray, G., Jacobs, M., Brombacher, F., ... Brown, G. D. (2011). The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes and Infection, 13(2), 198-201. https://doi.org/10.1016/j.micinf.2010.10.013

The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. / Marakalala, Mohlopheni J; Guler, Reto; Matika, Lungile; Murray, Graeme; Jacobs, Muazzam; Brombacher, Frank; Rothfuchs, Antonio Gigliotti; Sher, Alan; Brown, Gordon D.

In: Microbes and Infection, Vol. 13, No. 2, 02.2011, p. 198-201.

Research output: Contribution to journalArticle

Marakalala, MJ, Guler, R, Matika, L, Murray, G, Jacobs, M, Brombacher, F, Rothfuchs, AG, Sher, A & Brown, GD 2011, 'The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice', Microbes and Infection, vol. 13, no. 2, pp. 198-201. https://doi.org/10.1016/j.micinf.2010.10.013
Marakalala, Mohlopheni J ; Guler, Reto ; Matika, Lungile ; Murray, Graeme ; Jacobs, Muazzam ; Brombacher, Frank ; Rothfuchs, Antonio Gigliotti ; Sher, Alan ; Brown, Gordon D. / The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. In: Microbes and Infection. 2011 ; Vol. 13, No. 2. pp. 198-201.
@article{87195cd2301946c8a8ff0895734da33f,
title = "The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice",
abstract = "There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.",
keywords = "adaptor proteins, signal transducing, animals, cytokines, female, immunity, innate, membrane proteins, mice, mice, knockout, Mycobacterium tuberculosis, nerve tissue proteins, nuclear proteins, tuberculosis, pulmonary",
author = "Marakalala, {Mohlopheni J} and Reto Guler and Lungile Matika and Graeme Murray and Muazzam Jacobs and Frank Brombacher and Rothfuchs, {Antonio Gigliotti} and Alan Sher and Brown, {Gordon D}",
note = "{\circledC} 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.",
year = "2011",
month = "2",
doi = "10.1016/j.micinf.2010.10.013",
language = "English",
volume = "13",
pages = "198--201",
journal = "Microbes and Infection",
issn = "1286-4579",
publisher = "Elsevier Masson SAS",
number = "2",

}

TY - JOUR

T1 - The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

AU - Marakalala, Mohlopheni J

AU - Guler, Reto

AU - Matika, Lungile

AU - Murray, Graeme

AU - Jacobs, Muazzam

AU - Brombacher, Frank

AU - Rothfuchs, Antonio Gigliotti

AU - Sher, Alan

AU - Brown, Gordon D

N1 - © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

PY - 2011/2

Y1 - 2011/2

N2 - There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.

AB - There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.

KW - adaptor proteins, signal transducing

KW - animals

KW - cytokines

KW - female

KW - immunity, innate

KW - membrane proteins

KW - mice

KW - mice, knockout

KW - Mycobacterium tuberculosis

KW - nerve tissue proteins

KW - nuclear proteins

KW - tuberculosis, pulmonary

U2 - 10.1016/j.micinf.2010.10.013

DO - 10.1016/j.micinf.2010.10.013

M3 - Article

VL - 13

SP - 198

EP - 201

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 2

ER -