The teratogenic effects of thalidomide on limbs

Research output: Contribution to journalArticle

1 Citation (Scopus)
8 Downloads (Pure)

Abstract

Thalidomide remains notorious as a result of the damage it caused to children born to mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence of the drug to treat a range of conditions including erythema nodosum leprosum (a complication of leprosy) has led to a new generation of thalidomide damaged children being born in Brazil. Although thalidomide affects most of the developing tissues and organs of the body, the damage to the limbs is striking. Indeed phocomelia, the severe reduction or loss of the proximal long bones with retention of the distal hand/foot plate remains the stereotypical image of thalidomide. This review focuses on the type and range of damage thalidomide caused to the limbs, reviews current understanding of the mechanisms underlying thalidomide-induced limb malformations and outlines some of the challenges remaining in elucidating its teratogenicity.
Original languageEnglish
Pages (from-to)88-95
Number of pages8
JournalJournal of hand surgery-European volume
Volume44
Issue number1
Early online date18 Oct 2018
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Thalidomide
Extremities
Morning Sickness
Ectromelia
Erythema Nodosum
Leprosy
Brazil
Foot
Hand
Mothers
Bone and Bones
Pharmaceutical Preparations

Keywords

  • Phocomelia
  • limb development
  • cereblon
  • SALL4
  • anti-angiogenesis
  • cell death
  • vascular transition
  • Duane-radial-ray syndrome
  • Acro-renal ocular syndrome
  • IVIC syndrome
  • Acro-renal-ocular syndrome

ASJC Scopus subject areas

  • Surgery

Cite this

The teratogenic effects of thalidomide on limbs. / Vargesson, Neil.

In: Journal of hand surgery-European volume, Vol. 44, No. 1, 01.01.2019, p. 88-95.

Research output: Contribution to journalArticle

@article{c0817a0db54e44a6987b49feb5c2e3fa,
title = "The teratogenic effects of thalidomide on limbs",
abstract = "Thalidomide remains notorious as a result of the damage it caused to children born to mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence of the drug to treat a range of conditions including erythema nodosum leprosum (a complication of leprosy) has led to a new generation of thalidomide damaged children being born in Brazil. Although thalidomide affects most of the developing tissues and organs of the body, the damage to the limbs is striking. Indeed phocomelia, the severe reduction or loss of the proximal long bones with retention of the distal hand/foot plate remains the stereotypical image of thalidomide. This review focuses on the type and range of damage thalidomide caused to the limbs, reviews current understanding of the mechanisms underlying thalidomide-induced limb malformations and outlines some of the challenges remaining in elucidating its teratogenicity.",
keywords = "Phocomelia, limb development, cereblon, SALL4, anti-angiogenesis, cell death, vascular transition, Duane-radial-ray syndrome, Acro-renal ocular syndrome, IVIC syndrome, Acro-renal-ocular syndrome",
author = "Neil Vargesson",
note = "Acknowledgements Thanks to members of the Thalidomide Society for helpful discussions on thalidomide-induced limb damage. Funding The author disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research in the lab has previously been sponsored by Wellcome Trust, Royal Society and University of Aberdeen.",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/1753193418805249",
language = "English",
volume = "44",
pages = "88--95",
journal = "Journal of hand surgery-European volume",
issn = "1753-1934",
publisher = "SAGE PUBLICATIONS LTD",
number = "1",

}

TY - JOUR

T1 - The teratogenic effects of thalidomide on limbs

AU - Vargesson, Neil

N1 - Acknowledgements Thanks to members of the Thalidomide Society for helpful discussions on thalidomide-induced limb damage. Funding The author disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research in the lab has previously been sponsored by Wellcome Trust, Royal Society and University of Aberdeen.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Thalidomide remains notorious as a result of the damage it caused to children born to mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence of the drug to treat a range of conditions including erythema nodosum leprosum (a complication of leprosy) has led to a new generation of thalidomide damaged children being born in Brazil. Although thalidomide affects most of the developing tissues and organs of the body, the damage to the limbs is striking. Indeed phocomelia, the severe reduction or loss of the proximal long bones with retention of the distal hand/foot plate remains the stereotypical image of thalidomide. This review focuses on the type and range of damage thalidomide caused to the limbs, reviews current understanding of the mechanisms underlying thalidomide-induced limb malformations and outlines some of the challenges remaining in elucidating its teratogenicity.

AB - Thalidomide remains notorious as a result of the damage it caused to children born to mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence of the drug to treat a range of conditions including erythema nodosum leprosum (a complication of leprosy) has led to a new generation of thalidomide damaged children being born in Brazil. Although thalidomide affects most of the developing tissues and organs of the body, the damage to the limbs is striking. Indeed phocomelia, the severe reduction or loss of the proximal long bones with retention of the distal hand/foot plate remains the stereotypical image of thalidomide. This review focuses on the type and range of damage thalidomide caused to the limbs, reviews current understanding of the mechanisms underlying thalidomide-induced limb malformations and outlines some of the challenges remaining in elucidating its teratogenicity.

KW - Phocomelia

KW - limb development

KW - cereblon

KW - SALL4

KW - anti-angiogenesis

KW - cell death

KW - vascular transition

KW - Duane-radial-ray syndrome

KW - Acro-renal ocular syndrome

KW - IVIC syndrome

KW - Acro-renal-ocular syndrome

UR - http://www.scopus.com/inward/record.url?scp=85058751013&partnerID=8YFLogxK

U2 - 10.1177/1753193418805249

DO - 10.1177/1753193418805249

M3 - Article

VL - 44

SP - 88

EP - 95

JO - Journal of hand surgery-European volume

JF - Journal of hand surgery-European volume

SN - 1753-1934

IS - 1

ER -