The use of new imaging techniques to predict tumour response to therapy

Vanessa N Harry, Scott I Semple, David E Parkin, Fiona J Gilbert

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Imaging of tumour response to therapy has steadily evolved over the past few years as a result of advances in existing imaging modalities and the introduction of new functional techniques. The use of imaging as an early surrogate biomarker of response is appealing, because it might allow for a window of opportunity during which treatment regimens can be tailored accordingly, depending on the expected response. The clinical effect of this would ultimately result in a reduction in morbidity and undue costs. The aim of this review is to describe the potential of various new imaging techniques as biomarkers of early tumour response. We have reviewed the literature and identified studies that have assessed these techniques, such as diffusion-weighted MRI, dynamic contrast-enhanced MRI, magnetic resonance spectroscopy, and 18-fluorodeoxyglucose-PET as early response indicators, and highlight the current clinical awareness of their use.
Original languageEnglish
Pages (from-to)92-102
Number of pages11
JournalThe Lancet Oncology
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Keywords

  • positron emission tomography
  • cell lung cancer
  • standardized uptake value
  • functional diffusion map
  • advanced breast cancer
  • F-18 fluorodeoxyglucose uptake
  • advanced rectal carinoma
  • monitoring early response
  • contrast enhanced MRI
  • cervical cancer

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