The value of archival tissue blocks in understanding breast cancer biology

Thomas Dowsett; Eldo Verghese; Steven Pollock; Jennifer Pollard; Judith Heads; Andrew Hanby; Valerie Speirs

doi:10.1136/jclinpath-2013-201854

The value of archival tissue blocks in understanding breast cancer biology

Thomas Dowsett, Eldo Verghese, Steven Pollock, Jennifer Pollard, Judith Heads, Andrew Hanby, Valerie Speirs

University of Leeds

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Pathological reporting of breast cancer has evolved alongside scientific advances. Such advances have led to recognition of different molecular classes of breast cancer resulting in improved disease management. The aim of this study was to establish whether these advances could be applied to archival breast cancer cases dating from the 1940s to assess historical trends. Important observations included the marked differences in pathological reporting, size of tumour and in ERα expression throughout the decades.

Original language	English
Pages (from-to)	272-275
Number of pages	4
Journal	Journal of Clinical Pathology
Volume	67
Issue number	3
Early online date	29 Oct 2013
DOIs	https://doi.org/10.1136/jclinpath-2013-201854
Publication status	Published - Mar 2014
Externally published	Yes

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title = "The value of archival tissue blocks in understanding breast cancer biology",

abstract = "Pathological reporting of breast cancer has evolved alongside scientific advances. Such advances have led to recognition of different molecular classes of breast cancer resulting in improved disease management. The aim of this study was to establish whether these advances could be applied to archival breast cancer cases dating from the 1940s to assess historical trends. Important observations included the marked differences in pathological reporting, size of tumour and in ERα expression throughout the decades. ",

author = "Thomas Dowsett and Eldo Verghese and Steven Pollock and Jennifer Pollard and Judith Heads and Andrew Hanby and Valerie Speirs",

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doi = "10.1136/jclinpath-2013-201854",

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T1 - The value of archival tissue blocks in understanding breast cancer biology

AU - Dowsett, Thomas

AU - Verghese, Eldo

AU - Pollock, Steven

AU - Pollard, Jennifer

AU - Heads, Judith

AU - Hanby, Andrew

AU - Speirs, Valerie

PY - 2014/3

Y1 - 2014/3

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AB - Pathological reporting of breast cancer has evolved alongside scientific advances. Such advances have led to recognition of different molecular classes of breast cancer resulting in improved disease management. The aim of this study was to establish whether these advances could be applied to archival breast cancer cases dating from the 1940s to assess historical trends. Important observations included the marked differences in pathological reporting, size of tumour and in ERα expression throughout the decades.

U2 - 10.1136/jclinpath-2013-201854

DO - 10.1136/jclinpath-2013-201854

M3 - Article

C2 - 24170212

SN - 0021-9746

VL - 67

SP - 272

EP - 275

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

IS - 3

ER -

The value of archival tissue blocks in understanding breast cancer biology

Abstract

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