Theoretical and empirical dimensions of the Aberdeen Glaucoma Questionnaire: a cross sectional survey and principal component analysis

Maria Prior, Craig R Ramsay, Jennifer M Burr, Susan E Campbell, David J Jenkinson, Ryo Asoaka, Jillian J Francis

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Abstract

To develop patient-reported outcome instruments, statistical techniques (e.g., principal components analysis; PCA) are used to examine correlations among items and identify interrelated item subsets (empirical factors). However, interpretation and labelling of empirical factors is a subjective process, lacking precision or conceptual basis. We report a novel and reproducible method for mapping between theoretical and empirical factor structures. We illustrate the method using the pilot Aberdeen Glaucoma Questionnaire (AGQ), a new measure of glaucoma-related disability developed using the International Classification of Functioning and Disability (ICF) as a theoretical framework and tested in a sample representing the spectrum of glaucoma severity.
Original languageEnglish
Article number72
JournalBMC Ophthalmology
Volume13
DOIs
Publication statusPublished - 22 Nov 2013

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