TY - JOUR
T1 - There is an association between a genetic polymorphism in the ZNF259 gene involved in lipid metabolism and coronary artery disease
AU - Mirhafez, Seyed Reza
AU - Avan, Amir
AU - Khatamianfar, Sara
AU - Ghasemi, Faezeh
AU - Moohebati, Mohsen
AU - Ebrahimi, Mahmoud
AU - Ghazizadeh, Hamideh
AU - Ghayour-Mobarhan, Majid
AU - Pasdar, Alireza
N1 - Funding Information:
This study was supported by a grant (Majid Ghayour Mobarhan) from Mashhad University of Medical Sciences , Mashhad, Iran.
Acknowledgments:
We would like to thank Mashhad University of Medical Sciences Research Council for their financial supports.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: Recent genome-wide association studies (GWAS) have identified several genetic variants that influence the risk of dyslipidemia and coronary artery disease (CAD). In this study, we have examined the potential association of five SNPs variants related to lipid pathway, previously identified in GWAS studies (ZNF259 C>G, CETP I405VA/G, LPA C>T, LPLS447X and PSRC1 A>G) with CAD. Methods: Two hundred and ninety subjects including 194 patients with coronary artery disease and 96 controls were enrolled, followed by the analyses of anthropometric/biochemical parameters. Genotyping was carried out using Taq-Man real-time PCR based method. The association of the genetic polymorphisms with CAD was determined using univariate and multivariate analyses. Results: CAD patients had a higher (p < 0.05) fasting blood glucose (FBG), total cholesterol (TC), high sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C) and waist circumference. Results showed that subjects with CETP rs5882 genetic variant, AA&AG genotypes, had a higher risk of developing Coronary artery disease [OR: 2.1, 95% CI (1.2–4.1), p value = 0.015]. Also subjects who carried the G allele of the ZNF259 polymorphism were at an increased the risk of developing CAD [OR 1.86, 95% CI: 1.06–3.25, p value = 0.029] and had an increased TC, LDL and TG levels (p < 0.05). Furthermore, no statistically significant association was found between genetic polymorphisms of PSRC1 A>G, LPL S447X and LPA C>T and CAD. Conclusion: We identified a relationship between a genetic variant in CETP and ZNF259 gene with CAD and CAD and lipid profile, respectively. Further investigation in a larger population may help to investigate the value of emerging marker as a risk stratification marker in CAD and its risk factors.
AB - Background: Recent genome-wide association studies (GWAS) have identified several genetic variants that influence the risk of dyslipidemia and coronary artery disease (CAD). In this study, we have examined the potential association of five SNPs variants related to lipid pathway, previously identified in GWAS studies (ZNF259 C>G, CETP I405VA/G, LPA C>T, LPLS447X and PSRC1 A>G) with CAD. Methods: Two hundred and ninety subjects including 194 patients with coronary artery disease and 96 controls were enrolled, followed by the analyses of anthropometric/biochemical parameters. Genotyping was carried out using Taq-Man real-time PCR based method. The association of the genetic polymorphisms with CAD was determined using univariate and multivariate analyses. Results: CAD patients had a higher (p < 0.05) fasting blood glucose (FBG), total cholesterol (TC), high sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C) and waist circumference. Results showed that subjects with CETP rs5882 genetic variant, AA&AG genotypes, had a higher risk of developing Coronary artery disease [OR: 2.1, 95% CI (1.2–4.1), p value = 0.015]. Also subjects who carried the G allele of the ZNF259 polymorphism were at an increased the risk of developing CAD [OR 1.86, 95% CI: 1.06–3.25, p value = 0.029] and had an increased TC, LDL and TG levels (p < 0.05). Furthermore, no statistically significant association was found between genetic polymorphisms of PSRC1 A>G, LPL S447X and LPA C>T and CAD. Conclusion: We identified a relationship between a genetic variant in CETP and ZNF259 gene with CAD and CAD and lipid profile, respectively. Further investigation in a larger population may help to investigate the value of emerging marker as a risk stratification marker in CAD and its risk factors.
KW - Coronary artery disease
KW - Lipid metabolism
KW - Single nucleotide polymorphism
KW - Zink finger protein
UR - http://www.scopus.com/inward/record.url?scp=85064469514&partnerID=8YFLogxK
U2 - 10.1016/j.gene.2019.02.101
DO - 10.1016/j.gene.2019.02.101
M3 - Article
C2 - 30902787
AN - SCOPUS:85064469514
VL - 704
SP - 80
EP - 85
JO - Gene
JF - Gene
SN - 0378-1119
ER -