Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists

Thelma Polyviou, Yannis Pitsiladis, Wu Chean Lee, Takas Pantazis, Catherine Hambly, John R. Speakman, Dalia Malkova

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Abstract

ABSTRACT:

BACKGROUND: It has been shown that supplementation with creatine (Cr) and glycerol (Gly), when combined with glucose (Glu) necessary for the enhancement of Cr uptake by skeletal muscle, induces significant improvements in thermoregulatory and cardiovascular responses during exercise in the heat.

PURPOSE: To determine whether Cr/Gly-induced thermoregulatory and cardiovascular responses are maintained when the majority (~75%) of the Glu in the Cr/Gly supplement is replaced with the insulintropic agent alpha lipoic acid (Ala).

METHODS: 22 healthy endurance trained cyclists were randomly assigned to receive either 20¿g/day (4¿×¿5¿g/day) of Cr, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly and 150¿g/day (4¿×¿37.5¿g/day) of Glu or 20¿g/day (4¿×¿5¿g/day) of Cr monohydrate, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly (100¿g/day (4¿×¿25¿g/day) of Glu and 1000¿mg/day (4¿×¿250¿mg/day) of Ala for 7¿days for 7¿days. Exercise trials were conducted pre- and post-supplementation and involved 40¿min of constant-load cycling exercise at 70% O2 max by a self-paced 16.1¿km time trial at 30°C and 70% relative humidity.

RESULTS: Median and range values of TBW increased significantly by 2.1 (1.3-3.3) L and 1.8 (0.2-4.6) L in Cr/Gly/Glu and Cr/Gly/Glu/Ala groups respectively (P¿=¿0.03) and of BM not significantly by 1.8 (0.2-3.0) kg and 1.2 (0.5-2.1) kg in Cr/Gly/Glu and in Cr/Gly/Glu/Ala, respectively (P¿=¿0.75). During constant load exercise, heart rate (HR) and core temperature (Tcore) were significantly lower post-supplementation: HR was reduced on average by 3.3¿±¿2.1 beats/min and by 4.8¿±¿3.3 beats/min (mean ± SD) and Tcore by 0.2¿±¿0.1 (mean ± SD) in the Cr/Gly/Glu and Cr/Gly/Glu/Ala, respectively The reduction in HR and Tcore was not significantly different between the supplementation groups.

CONCLUSIONS: In comparison to the established hyper hydrating Cr/Gly/Glu supplement, supplement containing Cr/Gly/Ala and decreased amount of Glu provides equal improvements in thermoregulatory and cardiovascular responses during exercise in the heat.
Original languageEnglish
Article number29
Number of pages12
JournalJournal of the International Society of Sports Nutrition
Volume9
Issue number1
DOIs
Publication statusPublished - Jun 2012

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lipoic acid
Thioctic Acid
creatine
Creatine
Glycerol
glycerol
Glucose
glucose
exercise
heart rate
Heart Rate
Hot Temperature
heat
Humidity

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Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists. / Polyviou, Thelma; Pitsiladis, Yannis ; Lee, Wu Chean ; Pantazis, Takas ; Hambly, Catherine; Speakman, John R.; Malkova, Dalia .

In: Journal of the International Society of Sports Nutrition, Vol. 9, No. 1, 29, 06.2012.

Research output: Contribution to journalArticle

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title = "Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists",
abstract = "ABSTRACT:BACKGROUND: It has been shown that supplementation with creatine (Cr) and glycerol (Gly), when combined with glucose (Glu) necessary for the enhancement of Cr uptake by skeletal muscle, induces significant improvements in thermoregulatory and cardiovascular responses during exercise in the heat.PURPOSE: To determine whether Cr/Gly-induced thermoregulatory and cardiovascular responses are maintained when the majority (~75{\%}) of the Glu in the Cr/Gly supplement is replaced with the insulintropic agent alpha lipoic acid (Ala).METHODS: 22 healthy endurance trained cyclists were randomly assigned to receive either 20¿g/day (4¿×¿5¿g/day) of Cr, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly and 150¿g/day (4¿×¿37.5¿g/day) of Glu or 20¿g/day (4¿×¿5¿g/day) of Cr monohydrate, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly (100¿g/day (4¿×¿25¿g/day) of Glu and 1000¿mg/day (4¿×¿250¿mg/day) of Ala for 7¿days for 7¿days. Exercise trials were conducted pre- and post-supplementation and involved 40¿min of constant-load cycling exercise at 70{\%} O2 max by a self-paced 16.1¿km time trial at 30°C and 70{\%} relative humidity.RESULTS: Median and range values of TBW increased significantly by 2.1 (1.3-3.3) L and 1.8 (0.2-4.6) L in Cr/Gly/Glu and Cr/Gly/Glu/Ala groups respectively (P¿=¿0.03) and of BM not significantly by 1.8 (0.2-3.0) kg and 1.2 (0.5-2.1) kg in Cr/Gly/Glu and in Cr/Gly/Glu/Ala, respectively (P¿=¿0.75). During constant load exercise, heart rate (HR) and core temperature (Tcore) were significantly lower post-supplementation: HR was reduced on average by 3.3¿±¿2.1 beats/min and by 4.8¿±¿3.3 beats/min (mean ± SD) and Tcore by 0.2¿±¿0.1 (mean ± SD) in the Cr/Gly/Glu and Cr/Gly/Glu/Ala, respectively The reduction in HR and Tcore was not significantly different between the supplementation groups.CONCLUSIONS: In comparison to the established hyper hydrating Cr/Gly/Glu supplement, supplement containing Cr/Gly/Ala and decreased amount of Glu provides equal improvements in thermoregulatory and cardiovascular responses during exercise in the heat.",
author = "Thelma Polyviou and Yannis Pitsiladis and Lee, {Wu Chean} and Takas Pantazis and Catherine Hambly and Speakman, {John R.} and Dalia Malkova",
year = "2012",
month = "6",
doi = "10.1186/1550-2783-9-29",
language = "English",
volume = "9",
journal = "Journal of the International Society of Sports Nutrition",
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T1 - Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists

AU - Polyviou, Thelma

AU - Pitsiladis, Yannis

AU - Lee, Wu Chean

AU - Pantazis, Takas

AU - Hambly, Catherine

AU - Speakman, John R.

AU - Malkova, Dalia

PY - 2012/6

Y1 - 2012/6

N2 - ABSTRACT:BACKGROUND: It has been shown that supplementation with creatine (Cr) and glycerol (Gly), when combined with glucose (Glu) necessary for the enhancement of Cr uptake by skeletal muscle, induces significant improvements in thermoregulatory and cardiovascular responses during exercise in the heat.PURPOSE: To determine whether Cr/Gly-induced thermoregulatory and cardiovascular responses are maintained when the majority (~75%) of the Glu in the Cr/Gly supplement is replaced with the insulintropic agent alpha lipoic acid (Ala).METHODS: 22 healthy endurance trained cyclists were randomly assigned to receive either 20¿g/day (4¿×¿5¿g/day) of Cr, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly and 150¿g/day (4¿×¿37.5¿g/day) of Glu or 20¿g/day (4¿×¿5¿g/day) of Cr monohydrate, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly (100¿g/day (4¿×¿25¿g/day) of Glu and 1000¿mg/day (4¿×¿250¿mg/day) of Ala for 7¿days for 7¿days. Exercise trials were conducted pre- and post-supplementation and involved 40¿min of constant-load cycling exercise at 70% O2 max by a self-paced 16.1¿km time trial at 30°C and 70% relative humidity.RESULTS: Median and range values of TBW increased significantly by 2.1 (1.3-3.3) L and 1.8 (0.2-4.6) L in Cr/Gly/Glu and Cr/Gly/Glu/Ala groups respectively (P¿=¿0.03) and of BM not significantly by 1.8 (0.2-3.0) kg and 1.2 (0.5-2.1) kg in Cr/Gly/Glu and in Cr/Gly/Glu/Ala, respectively (P¿=¿0.75). During constant load exercise, heart rate (HR) and core temperature (Tcore) were significantly lower post-supplementation: HR was reduced on average by 3.3¿±¿2.1 beats/min and by 4.8¿±¿3.3 beats/min (mean ± SD) and Tcore by 0.2¿±¿0.1 (mean ± SD) in the Cr/Gly/Glu and Cr/Gly/Glu/Ala, respectively The reduction in HR and Tcore was not significantly different between the supplementation groups.CONCLUSIONS: In comparison to the established hyper hydrating Cr/Gly/Glu supplement, supplement containing Cr/Gly/Ala and decreased amount of Glu provides equal improvements in thermoregulatory and cardiovascular responses during exercise in the heat.

AB - ABSTRACT:BACKGROUND: It has been shown that supplementation with creatine (Cr) and glycerol (Gly), when combined with glucose (Glu) necessary for the enhancement of Cr uptake by skeletal muscle, induces significant improvements in thermoregulatory and cardiovascular responses during exercise in the heat.PURPOSE: To determine whether Cr/Gly-induced thermoregulatory and cardiovascular responses are maintained when the majority (~75%) of the Glu in the Cr/Gly supplement is replaced with the insulintropic agent alpha lipoic acid (Ala).METHODS: 22 healthy endurance trained cyclists were randomly assigned to receive either 20¿g/day (4¿×¿5¿g/day) of Cr, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly and 150¿g/day (4¿×¿37.5¿g/day) of Glu or 20¿g/day (4¿×¿5¿g/day) of Cr monohydrate, 2¿g .kg-1 BM per day (4¿×¿0.5¿g .kg-1 BM per day) of Gly (100¿g/day (4¿×¿25¿g/day) of Glu and 1000¿mg/day (4¿×¿250¿mg/day) of Ala for 7¿days for 7¿days. Exercise trials were conducted pre- and post-supplementation and involved 40¿min of constant-load cycling exercise at 70% O2 max by a self-paced 16.1¿km time trial at 30°C and 70% relative humidity.RESULTS: Median and range values of TBW increased significantly by 2.1 (1.3-3.3) L and 1.8 (0.2-4.6) L in Cr/Gly/Glu and Cr/Gly/Glu/Ala groups respectively (P¿=¿0.03) and of BM not significantly by 1.8 (0.2-3.0) kg and 1.2 (0.5-2.1) kg in Cr/Gly/Glu and in Cr/Gly/Glu/Ala, respectively (P¿=¿0.75). During constant load exercise, heart rate (HR) and core temperature (Tcore) were significantly lower post-supplementation: HR was reduced on average by 3.3¿±¿2.1 beats/min and by 4.8¿±¿3.3 beats/min (mean ± SD) and Tcore by 0.2¿±¿0.1 (mean ± SD) in the Cr/Gly/Glu and Cr/Gly/Glu/Ala, respectively The reduction in HR and Tcore was not significantly different between the supplementation groups.CONCLUSIONS: In comparison to the established hyper hydrating Cr/Gly/Glu supplement, supplement containing Cr/Gly/Ala and decreased amount of Glu provides equal improvements in thermoregulatory and cardiovascular responses during exercise in the heat.

U2 - 10.1186/1550-2783-9-29

DO - 10.1186/1550-2783-9-29

M3 - Article

VL - 9

JO - Journal of the International Society of Sports Nutrition

JF - Journal of the International Society of Sports Nutrition

SN - 1550-2783

IS - 1

M1 - 29

ER -