Three-Component, One-Pot Sequential Synthesis of 1,3-Disubstituted 5-Arylhydantoins

Francesca Olimpieri, Alessandro Volonterio, Matteo Zanda

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Reaction of carbodiimides with alpha-Br(Cl)-aryl acetic acids produces N,N'-substituted 5-arylhydantoins under very mild conditions and high yields. When the carbodiimides are generated in situ by Staudinger reaction, the process becomes a one-pot, three-component sequential synthesis of libraries of differently substituted 5-arylhydantoins.

Original languageEnglish
Pages (from-to)3016-3020
Number of pages5
JournalSynlett
Issue number19
DOIs
Publication statusPublished - 1 Dec 2008

Keywords

  • heterocycles
  • multicomponent reactions
  • combinatorial chemistry
  • carbodiimides
  • sequential synthesis
  • organic-synthesis
  • substituted hydantoins
  • tandem
  • chemistry
  • cycloadditions
  • methodology
  • acids

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