Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

A. Sharma, N. L. Sharma*, C. B. Lavy, A. E. Kiltie, F. C. Hamdy, J. Czernuszka

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a cancer's response to therapies. We review the materials that have been used in such models to date, including their fabrication techniques and the results from their study in cancer. Despite the variety of materials available, obstacles remain to perfecting an in vitro model system and we outline some of the challenges yet to be overcome.

Original languageEnglish
Pages (from-to)5809-5820
Number of pages12
JournalJournal of Materials Science
Volume49
Issue number17
DOIs
Publication statusPublished - Sep 2014

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