Thrombosis, markers of thrombotic risk, indwelling central venous catheters and antithrombotic prophylaxis using low-dose warfarin in subjects with malignant disease

M Ratcliffe, C Broadfoot, M Davidson, K F Kelly, M Greaves

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Abstract

Markers of thrombotic risk - fibrinogen, factor VIII and immunoglobulin G (IgG) anticardiolipin titres - were measured, and the presence of lupus anticoagulant and factor V Leiden were assessed in 84 patients with a solid or haematological malignancy. These patients were monitored, following the insertion of an indwelling venous catheter, for thrombosis. Fifty-five were given prophylactic low-dose warfarin. Over a mean of 15 weeks there were 10 (12%) thrombotic events in 10 patients. Seven were on warfarin. Haemorrhagic problems occurred in three (5%), all on warfarin. Of the 84 patients, 86% had raised fibrinogen levels, 37% elevated factor VIII and 44% raised anticardiolipin levels. Lupus anticoagulant was present in five and three were heterozygous for factor V Leiden. A high prevalence of a range of prothrombotic changes was confirmed and the frequent presence of low-titre anticardiolipin antibody in subjects with malignancy demonstrated. However, none of these parameters predicted the development of thrombosis (P > 0.05).

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalClinical and Laboratory Haematology
Volume21
Publication statusPublished - 1999

Keywords

  • catheters
  • malignancy markers
  • prophylaxis
  • thrombosis
  • LOW-MOLECULAR-WEIGHT
  • CANCER-PATIENTS
  • LUPUS ANTICOAGULANT
  • ACCESS DEVICES
  • HEPARIN
  • COMPLICATIONS

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