Tianchimycins A-B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis

Xiaoling Wang; Jioji Tabudravu; Marcel Jaspars; Hai Deng

doi:10.1016/j.tet.2013.05.094

Tianchimycins A-B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis

Xiaoling Wang, Jioji Tabudravu, Marcel Jaspars, Hai Deng^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Two new 16-membered macrolactone-type polyketides, Tianchimycin A (1) and B (2), were isolated from the rare actinomycete Saccharothrix xinjiangensis NRRL B-24321, together with one known compound, swalpamycin B (3). The isolated compounds were structurally characterized using 1D and 2D NMR and MS techniques. The antimicrobial activities of 1-3 were determined against a panel of Gram-negative and Gram-positive bacteria including five hospital isolates from NHS Grampian. Compound 3 displayed moderate antibacterial activity against three MRSA clinical isolates and Enterococcus faecalis ATCC 29212.

Original language	English
Pages (from-to)	6060-6064
Number of pages	5
Journal	Tetrahedron
Volume	69
Issue number	30
Early online date	24 May 2013
DOIs	https://doi.org/10.1016/j.tet.2013.05.094
Publication status	Published - 29 Jul 2013

Keywords

16-membered macrolides
rare actinomycete
Saccharothrix xinjiangensis
structural elucidation

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10.1016/j.tet.2013.05.094

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abstract = "Two new 16-membered macrolactone-type polyketides, Tianchimycin A (1) and B (2), were isolated from the rare actinomycete Saccharothrix xinjiangensis NRRL B-24321, together with one known compound, swalpamycin B (3). The isolated compounds were structurally characterized using 1D and 2D NMR and MS techniques. The antimicrobial activities of 1-3 were determined against a panel of Gram-negative and Gram-positive bacteria including five hospital isolates from NHS Grampian. Compound 3 displayed moderate antibacterial activity against three MRSA clinical isolates and Enterococcus faecalis ATCC 29212.",

keywords = "16-membered macrolides, rare actinomycete, Saccharothrix xinjiangensis, structural elucidation",

author = "Xiaoling Wang and Jioji Tabudravu and Marcel Jaspars and Hai Deng",

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AU - Wang, Xiaoling

AU - Tabudravu, Jioji

AU - Jaspars, Marcel

AU - Deng, Hai

PY - 2013/7/29

Y1 - 2013/7/29

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AB - Two new 16-membered macrolactone-type polyketides, Tianchimycin A (1) and B (2), were isolated from the rare actinomycete Saccharothrix xinjiangensis NRRL B-24321, together with one known compound, swalpamycin B (3). The isolated compounds were structurally characterized using 1D and 2D NMR and MS techniques. The antimicrobial activities of 1-3 were determined against a panel of Gram-negative and Gram-positive bacteria including five hospital isolates from NHS Grampian. Compound 3 displayed moderate antibacterial activity against three MRSA clinical isolates and Enterococcus faecalis ATCC 29212.

KW - 16-membered macrolides

KW - rare actinomycete

KW - Saccharothrix xinjiangensis

KW - structural elucidation

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DO - 10.1016/j.tet.2013.05.094

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JO - Tetrahedron

JF - Tetrahedron

IS - 30

ER -

Tianchimycins A-B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis

Abstract

Keywords

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