Tianchimycins A-B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis

Xiaoling Wang, Jioji Tabudravu, Marcel Jaspars, Hai Deng (Corresponding Author)

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Abstract

Two new 16-membered macrolactone-type polyketides, Tianchimycin A (1) and B (2), were isolated from the rare actinomycete Saccharothrix xinjiangensis NRRL B-24321, together with one known compound, swalpamycin B (3). The isolated compounds were structurally characterized using 1D and 2D NMR and MS techniques. The antimicrobial activities of 1-3 were determined against a panel of Gram-negative and Gram-positive bacteria including five hospital isolates from NHS Grampian. Compound 3 displayed moderate antibacterial activity against three MRSA clinical isolates and Enterococcus faecalis ATCC 29212.
Original languageEnglish
Pages (from-to)6060-6064
Number of pages5
JournalTetrahedron
Volume69
Issue number30
Early online date24 May 2013
DOIs
Publication statusPublished - 29 Jul 2013

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Keywords

  • 16-membered macrolides
  • rare actinomycete
  • Saccharothrix xinjiangensis
  • structural elucidation

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