Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity

Leonie C Ruddick-Collins, Peter J Morgan, Claire L Fyfe, Joao A N Filipe, Graham W Horgan, Klaas R Westerterp, Jonathan D Johnston, Alexandra M Johnstone* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Morning loaded calorie intake in humans has been advocated as a dietary strategy to improve weight loss. This is also supported by animal studies suggesting time of eating can prevent weight gain. However, the underlying mechanisms through which timing of eating could promote weight loss in humans are unclear. In a randomized crossover trial (NCT03305237), 30 subjects with obesity/overweight underwent two 4-week calorie-restricted but isoenergetic weight loss diets, with morning loaded or evening loaded calories (45%:35%:20% versus 20%:35%:45% calories at breakfast, lunch, and dinner, respectively). We demonstrate no differences in total daily energy expenditure or resting metabolic rate related to the timing of calorie distribution, and no difference in weight loss. Participants consuming the morning loaded diet reported significantly lower hunger. Thus, morning loaded intake (big breakfast) may assist with compliance to weight loss regime through a greater suppression of appetite.

Original languageEnglish
Pages (from-to)1472-1485.e6
Number of pages21
JournalCell Metabolism
Volume34
Issue number10
Early online date4 Oct 2022
DOIs
Publication statusPublished - 4 Oct 2022

Keywords

  • calorie distribution
  • chrono-nutrition
  • time of eating
  • body weight
  • obesity
  • energy intake
  • energy expenditure
  • appetite control

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