Tissue architecture and cell morphology of squamous cell carcinomas compared to granular cell tumours' pseudo-epitheliomatous hyperplasia and to normal oral mucosae

R Abu-Eid*, G Landini

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Squamous cell carcinoma (SCC) is the most common malignant lesion of the oral cavity. One important diagnostic problem involves differentiating histopathologically between SCC and pseudo-epitheliomatous hyperplasia (PEH) of the covering epithelium present in granular cell tumour (GCT) (a benign tumour), mimicking the invasive patterns of SCC. The complexity of the epithelial connective tissue interface (ECTI) in 84 profiles from normal oral mucosa, SCC and GCT-PEH cases was analyzed using both global and local fractal dimensions. Segmentation of the epithelial compartments into theoretical cell areas was performed using a space partition procedure and the morphological properties of these "cells" were analyzed. The complexity of the GCT-PEH ECTI profiles was marginally but significantly higher than that of SCC, which was significantly higher than normal ECTI profiles. The combined fractal and cell morphology data allowed up to 100%, and 96% correct discrimination between SCC and normal oral mucosa and between SCC and GCT-PEH respectively. In conclusion, we found that the architectural features of SCC, normal oral mucosa and GCT-PEH show differences that, when quantified, could be used for aiding in the diagnostic process.

Original languageEnglish
Title of host publicationFractals in Biology and Medicine, Vol IV
EditorsGA Losa, D Merlini, TF Nonnenmacher, ER Weibel
PublisherBIRKHAUSER VERLAG AG
Pages155-164
Number of pages10
ISBN (Print)3-7643-7172-2
Publication statusPublished - 2005
Event4th International Symposium on Fractals in Biology and Medicine - Ascona, Switzerland
Duration: 10 Mar 200413 Mar 2004

Publication series

NameMATHEMATICS AND BIOSCIENCES IN INTERACTION
PublisherBIRKHAUSER VERLAG AG

Conference

Conference4th International Symposium on Fractals in Biology and Medicine
CountrySwitzerland
CityAscona
Period10/03/0413/03/04

Keywords

  • EPITHELIAL DYSPLASIA
  • QUANTIFICATION
  • LESIONS
  • MYOBLASTOMA
  • INTERFACE
  • CAVITY
  • LEVEL

Cite this

Abu-Eid, R., & Landini, G. (2005). Tissue architecture and cell morphology of squamous cell carcinomas compared to granular cell tumours' pseudo-epitheliomatous hyperplasia and to normal oral mucosae. In GA. Losa, D. Merlini, TF. Nonnenmacher, & ER. Weibel (Eds.), Fractals in Biology and Medicine, Vol IV (pp. 155-164). (MATHEMATICS AND BIOSCIENCES IN INTERACTION). BIRKHAUSER VERLAG AG.

Tissue architecture and cell morphology of squamous cell carcinomas compared to granular cell tumours' pseudo-epitheliomatous hyperplasia and to normal oral mucosae. / Abu-Eid, R; Landini, G.

Fractals in Biology and Medicine, Vol IV. ed. / GA Losa; D Merlini; TF Nonnenmacher; ER Weibel. BIRKHAUSER VERLAG AG, 2005. p. 155-164 (MATHEMATICS AND BIOSCIENCES IN INTERACTION).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abu-Eid, R & Landini, G 2005, Tissue architecture and cell morphology of squamous cell carcinomas compared to granular cell tumours' pseudo-epitheliomatous hyperplasia and to normal oral mucosae. in GA Losa, D Merlini, TF Nonnenmacher & ER Weibel (eds), Fractals in Biology and Medicine, Vol IV. MATHEMATICS AND BIOSCIENCES IN INTERACTION, BIRKHAUSER VERLAG AG, pp. 155-164, 4th International Symposium on Fractals in Biology and Medicine, Ascona, Switzerland, 10/03/04.
Abu-Eid R, Landini G. Tissue architecture and cell morphology of squamous cell carcinomas compared to granular cell tumours' pseudo-epitheliomatous hyperplasia and to normal oral mucosae. In Losa GA, Merlini D, Nonnenmacher TF, Weibel ER, editors, Fractals in Biology and Medicine, Vol IV. BIRKHAUSER VERLAG AG. 2005. p. 155-164. (MATHEMATICS AND BIOSCIENCES IN INTERACTION).
Abu-Eid, R ; Landini, G. / Tissue architecture and cell morphology of squamous cell carcinomas compared to granular cell tumours' pseudo-epitheliomatous hyperplasia and to normal oral mucosae. Fractals in Biology and Medicine, Vol IV. editor / GA Losa ; D Merlini ; TF Nonnenmacher ; ER Weibel. BIRKHAUSER VERLAG AG, 2005. pp. 155-164 (MATHEMATICS AND BIOSCIENCES IN INTERACTION).
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AB - Squamous cell carcinoma (SCC) is the most common malignant lesion of the oral cavity. One important diagnostic problem involves differentiating histopathologically between SCC and pseudo-epitheliomatous hyperplasia (PEH) of the covering epithelium present in granular cell tumour (GCT) (a benign tumour), mimicking the invasive patterns of SCC. The complexity of the epithelial connective tissue interface (ECTI) in 84 profiles from normal oral mucosa, SCC and GCT-PEH cases was analyzed using both global and local fractal dimensions. Segmentation of the epithelial compartments into theoretical cell areas was performed using a space partition procedure and the morphological properties of these "cells" were analyzed. The complexity of the GCT-PEH ECTI profiles was marginally but significantly higher than that of SCC, which was significantly higher than normal ECTI profiles. The combined fractal and cell morphology data allowed up to 100%, and 96% correct discrimination between SCC and normal oral mucosa and between SCC and GCT-PEH respectively. In conclusion, we found that the architectural features of SCC, normal oral mucosa and GCT-PEH show differences that, when quantified, could be used for aiding in the diagnostic process.

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