Tixocortol pivalate: What is the right concentration?

Manjunatha Kalavala, Barry N. Statham, Cathy M. Green, Clodagh King, Anthony Ormerod, Jane Sansom, John S. C. English, Mark S. Wilkinson, Helen Horne, David Gawkrodger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Tixocortol pivalate (TP) is a good marker for hydrocortisone allergy. The concentration of TP to be included in the standard series for patch testing has been the subject of debate. The objective of this study was to investigate the right concentration of TP to be included in the standard series for patch testing. 3747 consecutive patients with dermatitis were patch tested simultaneously with TP 1% and 0.1% in petrolatum at 9 centres in the UK from August 2004 to December 2005. Statistical analysis of the results was performed using STATISTICA, version 6 software. 41 patients had positive reactions of current or past relevance. 20 were positive for both concentrations, 13 positive only for TP 1% concentration, and 8 positive only for 0.1% concentration. Statistical analysis, using a two-tailed difference in proportions test, did not show a significant difference between the 2 concentrations (P=0.21). There was no statistically significant difference between the 2 concentrations of TP. The number of allergens that can be included in the standard series is limited for practical considerations. When testing for screening purposes, TP 1% is recommended.
Original languageEnglish
Pages (from-to)44-46
Number of pages3
JournalContact Dermatitis
Volume57
Issue number1
Early online date15 Jun 2007
DOIs
Publication statusPublished - Jul 2007

Keywords

  • administration, topical
  • dermatitis, allergic contact
  • humans
  • hydrocortisone
  • patch tests
  • corticosteroid
  • medicaments
  • standard series
  • tixocortol pivalate

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    Kalavala, M., Statham, B. N., Green, C. M., King, C., Ormerod, A., Sansom, J., English, J. S. C., Wilkinson, M. S., Horne, H., & Gawkrodger, D. (2007). Tixocortol pivalate: What is the right concentration? Contact Dermatitis, 57(1), 44-46. https://doi.org/10.1111/j.1600-0536.2007.01136.x