Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge with no standard treatment and high rates of relapse. Based on our recent discoveries in mouse models, we tested the efficacy of using topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report here on the first four patients, who all displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.
- Fonsecaea pedrosoi
- innate immunity
- antifungal treatment
Sousa, M. D. G., Belda Junior, W., Spina, R., Lota, P. R., Valente, N. S., Brown, G. D., ... Benard, G. (2014). Topical Application of Imiquimod as a Treatment for Chromoblastomycosis. Clinical Infectious Diseases, 58(12), 1734-1737. https://doi.org/10.1093/cid/ciu168