Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

Maria Da Gloria Sousa; Walter Belda Junior; Ricardo Spina; Priscila Ramos Lota; Neusa Sakai Valente; Gordon D. Brown; Paulo Ricardo Criado; Gil  Benard

doi:10.1093/cid/ciu168

Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

Maria Da Gloria Sousa, Walter Belda Junior, Ricardo Spina, Priscila Ramos Lota, Neusa Sakai Valente, Gordon D. Brown, Paulo Ricardo Criado, Gil Benard

Applied Medicine

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Abstract

Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge with no standard treatment and high rates of relapse. Based on our recent discoveries in mouse models, we tested the efficacy of using topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report here on the first four patients, who all displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.

Original language	English
Pages (from-to)	1734-1737
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	58
Issue number	12
Early online date	14 Mar 2014
DOIs	https://doi.org/10.1093/cid/ciu168
Publication status	Published - 15 Jun 2014

Keywords

imiquimod
chromoblastomycosis
Fonsecaea pedrosoi
innate immunity
antifungal treatment

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10.1093/cid/ciu168Licence: CC BY

Clin Infect Dis.-2014-de Sousa-1734-7
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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AU - Criado, Paulo Ricardo

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Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

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Keywords

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