Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

Maria Da Gloria Sousa, Walter Belda Junior, Ricardo Spina, Priscila Ramos Lota, Neusa Sakai Valente, Gordon D. Brown, Paulo Ricardo Criado, Gil Benard

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Abstract

Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge with no standard treatment and high rates of relapse. Based on our recent discoveries in mouse models, we tested the efficacy of using topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report here on the first four patients, who all displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.
Original languageEnglish
Pages (from-to)1734-1737
Number of pages4
JournalClinical Infectious Diseases
Volume58
Issue number12
Early online date14 Mar 2014
DOIs
Publication statusPublished - 15 Jun 2014

Keywords

  • imiquimod
  • chromoblastomycosis
  • Fonsecaea pedrosoi
  • innate immunity
  • antifungal treatment

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  • Cite this

    Sousa, M. D. G., Belda Junior, W., Spina, R., Lota, P. R., Valente, N. S., Brown, G. D., Criado, P. R., & Benard, G. (2014). Topical Application of Imiquimod as a Treatment for Chromoblastomycosis. Clinical Infectious Diseases, 58(12), 1734-1737. https://doi.org/10.1093/cid/ciu168