Total or Partial Knee Arthroplasty Trial - TOPKAT: study protocol for a randomised controlled trial

David Beard, Andrew Price, Jonathan Cook, Ray Fitzpatrick, Andrew Carr, Marion Campbell, Helen Doll, Helen Campbell, Nigel Arden, Cushla Cooper, Loretta Davies, David Murray

Research output: Contribution to journalArticle

25 Citations (Scopus)
4 Downloads (Pure)


In the majority of patients with osteoarthritis of the knee the disease originates in the medial compartment. There are two fundamentally different approaches to knee replacement for patients with unicompartmental disease: some surgeons feel that it is always best to replace both the knee compartments with a total knee replacement (TKR); whereas others feel it is best to replace just the damaged component of the knee using a partial or unicompartment replacement (UKR). Both interventions are established and well-documented procedures. Little evidence exists to prove the clinical and cost-effectiveness of either management option. This provides an explanation for the high variation in treatment of choice by individual surgeons for the same knee pathology.The aim of the TOPKAT study will be to assess the clinical and cost effectiveness of TKRs compared to UKRs in patients with medial compartment osteoarthritis.
Original languageEnglish
Article number292
Publication statusPublished - 12 Sep 2013



  • medical compartment osteoarthritis
  • total knee replacement
  • unicompartmental knee replacement
  • equipoise
  • expertise

Cite this