Abstract
There are many challenges to overcome in order to properly understand both the exposure to, and effects of, endocrine disruptors (EDs). This is particularly true with respect to fetal life where ED exposures are a major issue requiring toxicokinetic studies of materno-fetal exchange and identification of pathophysiological consequences. The sheep, a monotocous large size species is very suitable for in utero fetal catheterization allowing a modelling approach predictive of human fetal exposure. Predicting adverse effects of EDs on human health is frequently impeded by the wide interspecies differences in the regulation of endocrine functions and their effect on biological processes. Because of its similarity to humans as regards gestational and thyroid physiologies and brain ontogeny, the sheep constitutes a highly appropriate model to move one step further on thyroid disruptor hazard assessment. As a grazing animal, sheep has also been proven to be useful in the evaluation of the consequences of chronic environmental exposure to “real-life” complex mixtures at different stages of the reproductive life cycle.
Original language | English |
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Article number | 110711 |
Journal | Molecular and Cellular Endocrinology |
Volume | 505 |
Early online date | 16 Jan 2020 |
DOIs | |
Publication status | Published - 5 Apr 2020 |
Bibliographical note
The 3 case studies reviewed in this article were supported by funders including: SRF Academic Scholarship Award 2013, the Wellcome Trust (080388), the European Community’s Seventh Framework Programme under grant agreement no 212885 and French Region Midi-Pyrénées [31000642] the French National Research Program for Environmental and Occupational Health of Anses [grant number 2015/1/112, 2015] and the French National Research Agency [ANR-13-CESA0007-1].Keywords
- Endocrine disruptors
- Sheep model
- Fetal exposure
- Thyroid
- Mixture
- SEWAGE-SLUDGE
- ENVIRONMENTAL-POLLUTANTS
- ALKYL PHENOL CONCENTRATIONS
- INDUCED THYROID DISRUPTION
- MATERNAL HYPOTHYROXINEMIA
- THYROXINE-BINDING GLOBULIN
- PREGNANE X RECEPTOR
- URINARY BISPHENOL-A
- IN-VITRO
- PLACENTAL BLOOD-FLOW