Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells

Severine Grouffaud, Stephen Whisson, Paul Birch, Pieter van West

Research output: Contribution to journalLiterature review

9 Citations (Scopus)

Abstract

The most notorious oomycetes, such as Phytophthora infestans, are pathogens of higher plants, although numerous other species of these fungal-like microorganisms infect algae, crustacea, nematodes, fish and mammals. While there is now ample evidence that oomycetes and fungi deliver effector proteins inside the host cell during infection, like bacteria using the well characterised type III secretion system, the mechanism employed by eukaryotic pathogens remains unclear. In oomycetes this process depends on an N-terminal motif defined by a short conserved amino acid sequence (RxLR) located near the signal peptide of many secreted proteins. This motif resembles the host-cell targeting signal found in virulence proteins from the malaria parasite Plasmodium falciparum (RxLxE/D/Q).

This review will focus on the recent findings contributing to the understanding of the delivery of oomycete effector molecules into the host cells, with emphasis on how they compare with various models proposed for filamentous fungi and the malaria parasite.
Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalFungal Biology Reviews
Volume24
Issue number1-2
DOIs
Publication statusPublished - May 2010

Fingerprint

Oomycetes
Parasites
Proteins
Fungi
Phytophthora infestans
Crustacea
Falciparum Malaria
Protein Sorting Signals
Malaria
Virulence
Mammals
Amino Acid Sequence
Fishes
Bacteria
Infection

Keywords

  • effector
  • malaria
  • oomycete
  • PEXEL
  • phytophthora
  • plasmodium
  • RxLR

Cite this

Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells. / Grouffaud, Severine; Whisson, Stephen; Birch, Paul; van West, Pieter.

In: Fungal Biology Reviews, Vol. 24, No. 1-2, 05.2010, p. 27-36.

Research output: Contribution to journalLiterature review

Grouffaud, Severine ; Whisson, Stephen ; Birch, Paul ; van West, Pieter. / Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells. In: Fungal Biology Reviews. 2010 ; Vol. 24, No. 1-2. pp. 27-36.
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