Towards multifunctional antioxidants: Synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties

Catriona A. Collins, Fiona H. Fry, Andrea L. Holme, Anthie Yiakouvaki, Abdullah Al-Qenaei, Charareh Pourzand, Clans Jacob*

*Corresponding author for this work

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Numerous human diseases are linked to a biochemical condition known as oxidative stress (OS). Antioxidants are therefore becoming increasingly important as potential disease prevention and therapeutic agents. Since OS is a multi-stressor event, agents combining a range of different antioxidant properties, such as redox catalysis and metal binding, might be more effective and selective than mono-functional agents. Selenium derivatives of aniline and pyridine combine redox activity with metal binding properties. These multifunctional agents have a distinct electrochemical profile, and exhibit good catalytic activity in the glutathione peroxidase mimic and metallothionein assays. They also show antioxidant activity in a skin cell model of UVA-induced stress. These compounds might therefore provide the basis for novel agents combining two or more distinct antioxidant properties.

Original languageEnglish
Pages (from-to)1541-1546
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume3
Issue number8
Early online date18 Mar 2005
DOIs
Publication statusPublished - 21 Apr 2005

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