Abstract
Numerous human diseases are linked to a biochemical condition known as oxidative stress (OS). Antioxidants are therefore becoming increasingly important as potential disease prevention and therapeutic agents. Since OS is a multi-stressor event, agents combining a range of different antioxidant properties, such as redox catalysis and metal binding, might be more effective and selective than mono-functional agents. Selenium derivatives of aniline and pyridine combine redox activity with metal binding properties. These multifunctional agents have a distinct electrochemical profile, and exhibit good catalytic activity in the glutathione peroxidase mimic and metallothionein assays. They also show antioxidant activity in a skin cell model of UVA-induced stress. These compounds might therefore provide the basis for novel agents combining two or more distinct antioxidant properties.
Original language | English |
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Pages (from-to) | 1541-1546 |
Number of pages | 6 |
Journal | Organic and Biomolecular Chemistry |
Volume | 3 |
Issue number | 8 |
Early online date | 18 Mar 2005 |
DOIs | |
Publication status | Published - 21 Apr 2005 |
Externally published | Yes |