Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures: a new threat from ketoprofen

Vinny Naidoo, Kerri Wolter, Duncan Cromarty, Maria Diekmann, Neil Duncan, Andrew Alexander Meharg, Mark A. Taggart, Leon Venter, Richard Cuthbert

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Three Gyps vulture species are on the brink of extinction in South Asia owing to the veterinary non-steroidal anti-inflammatory drug (NSAID) diclofenac. Carcasses of domesticated ungulates are the main food source for Asia's vultures and birds die from kidney failure after consuming diclofenac-contaminated tissues. Here, we report on the safety testing of the NSAID ketoprofen, which was not reported to cause mortality in clinical treatment of scavenging birds and is rapidly eliminated from livestock tissues. Safety testing was undertaken using captive non-releasable Cape griffon vultures (Gyps coprotheres) and wild-caught African white-backed vultures (G. africanus), both previously identified as susceptible to diclofenac and suitable surrogates. Ketoprofen doses ranged from 0.5 to 5 mg kg(-1) vulture body weight, based upon recommended veterinary guidelines and maximum levels of exposure for wild vultures (estimated as 1.54 mg kg(-1)). Doses were administered by oral gavage or through feeding tissues from cattle dosed with ketoprofen at 6 mg kg(-1) cattle body weight, before slaughter. Mortalities occurred at dose levels of 1.5 and 5 mg kg(-1) vulture body weight (within the range recommended for clinical treatment) with the same clinical signs as observed for diclofenac. Surveys of livestock carcasses in India indicate that toxic levels of residual ketoprofen are already present in vulture food supplies. Consequently, we strongly recommend that ketoprofen is not used for veterinary treatment of livestock in Asia and in other regions of the world where vultures access livestock carcasses. The only alternative to diclofenac that should be promoted as safe for vultures is the NSAID meloxicam.

Original languageEnglish
Pages (from-to)339-341
Number of pages3
JournalBiology Letters
Volume6
Issue number3
DOIs
Publication statusPublished - 23 Jun 2010

Keywords

  • Gyps
  • vultures
  • toxicity
  • ketoprofen
  • diclofenac
  • NSAIDs
  • critically endangered vultures
  • diclofenac residues
  • population
  • decline
  • India

Cite this

Naidoo, V., Wolter, K., Cromarty, D., Diekmann, M., Duncan, N., Meharg, A. A., ... Cuthbert, R. (2010). Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures: a new threat from ketoprofen. Biology Letters, 6(3), 339-341. https://doi.org/10.1098/rsbl.2009.0818

Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures : a new threat from ketoprofen. / Naidoo, Vinny; Wolter, Kerri; Cromarty, Duncan; Diekmann, Maria; Duncan, Neil; Meharg, Andrew Alexander; Taggart, Mark A.; Venter, Leon; Cuthbert, Richard.

In: Biology Letters, Vol. 6, No. 3, 23.06.2010, p. 339-341.

Research output: Contribution to journalArticle

Naidoo, V, Wolter, K, Cromarty, D, Diekmann, M, Duncan, N, Meharg, AA, Taggart, MA, Venter, L & Cuthbert, R 2010, 'Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures: a new threat from ketoprofen' Biology Letters, vol. 6, no. 3, pp. 339-341. https://doi.org/10.1098/rsbl.2009.0818
Naidoo V, Wolter K, Cromarty D, Diekmann M, Duncan N, Meharg AA et al. Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures: a new threat from ketoprofen. Biology Letters. 2010 Jun 23;6(3):339-341. https://doi.org/10.1098/rsbl.2009.0818
Naidoo, Vinny ; Wolter, Kerri ; Cromarty, Duncan ; Diekmann, Maria ; Duncan, Neil ; Meharg, Andrew Alexander ; Taggart, Mark A. ; Venter, Leon ; Cuthbert, Richard. / Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures : a new threat from ketoprofen. In: Biology Letters. 2010 ; Vol. 6, No. 3. pp. 339-341.
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