Tracking Genomic Cancer Evolution for Precision Medicine

The Lung TRACERx Study

Mariam Jamal-Hanjani, Alan Hackshaw, Yenting Ngai, Jacqueline Shaw, Caroline Dive, Sergio Quezada, Gary Middleton, Elza de Bruin, John Le Quesne, Seema Shafi, Mary Falzon, Stuart Horswell, Fiona Blackhall, Iftekhar Khan, Sam Janes, Marianne Nicolson, David Lawrence, Martin Forster, Dean Fennell, Siow Ming Lee & 51 others Jason Lester, Keith Kerr, Salli Muller, Natasha Iles, Sean Smith, Nirupa Murugaesu, Richard Mitter, Max Salm, Aengus Stuart, Nik Matthews, Haydn Adams, Tanya Ahmad, Richard Attanoos, Jonathan Bennett, Nicolai Juul Birkbak, Richard Booton, Ged Brady, Keith Buchan, Arrigo Capitano, Mahendran Chetty, Mark Cobbold, Philip Crosbie, Helen Davies, Alan Denison, Madhav Djearman, Jacki Goldman, Tom Haswell, Leena Joseph, Malgorzata Kornaszewska, Matthew Krebs, Gerald Langman, Mairead MacKenzie, Joy Millar, Bruno Morgan, Babu Naidu, Daisuke Nonaka, Karl Peggs, Catrin Pritchard, Hardy Remmen, Andrew Rowan, Rajesh Shah, Elaine Smith, Yvonne Summers, Magali Taylor, Selvaraju Veeriah, David Waller, Ben Wilcox, Maggie Wilcox, Ian Woolhouse, Nicholas McGranahan, Charles Swanton*

*Corresponding author for this work

Research output: Contribution to journalArticle

95 Citations (Scopus)
6 Downloads (Pure)

Abstract

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

Original languageEnglish
Article numbere1001906
Pages (from-to)1-7
Number of pages7
JournalPLoS Biology
Volume12
Issue number7
DOIs
Publication statusPublished - 8 Jul 2014

Fingerprint

Precision Medicine
Medicine
Tumors
medicine
lungs
lung neoplasms
genomics
Lung
neoplasms
Cells
Trajectories
Non-Small Cell Lung Carcinoma
Neoplasms
therapeutics
trajectories
Sampling
Genetic Heterogeneity
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cells
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Jamal-Hanjani, M., Hackshaw, A., Ngai, Y., Shaw, J., Dive, C., Quezada, S., ... Swanton, C. (2014). Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study. PLoS Biology, 12(7), 1-7. [e1001906]. https://doi.org/10.1371/journal.pbio.1001906

Tracking Genomic Cancer Evolution for Precision Medicine : The Lung TRACERx Study. / Jamal-Hanjani, Mariam; Hackshaw, Alan; Ngai, Yenting; Shaw, Jacqueline; Dive, Caroline; Quezada, Sergio; Middleton, Gary; de Bruin, Elza; Le Quesne, John; Shafi, Seema; Falzon, Mary; Horswell, Stuart; Blackhall, Fiona; Khan, Iftekhar; Janes, Sam; Nicolson, Marianne; Lawrence, David; Forster, Martin; Fennell, Dean; Lee, Siow Ming; Lester, Jason; Kerr, Keith; Muller, Salli; Iles, Natasha; Smith, Sean; Murugaesu, Nirupa; Mitter, Richard; Salm, Max; Stuart, Aengus; Matthews, Nik; Adams, Haydn; Ahmad, Tanya; Attanoos, Richard; Bennett, Jonathan; Birkbak, Nicolai Juul; Booton, Richard; Brady, Ged; Buchan, Keith; Capitano, Arrigo; Chetty, Mahendran; Cobbold, Mark; Crosbie, Philip; Davies, Helen; Denison, Alan; Djearman, Madhav; Goldman, Jacki; Haswell, Tom; Joseph, Leena; Kornaszewska, Malgorzata; Krebs, Matthew; Langman, Gerald; MacKenzie, Mairead; Millar, Joy; Morgan, Bruno; Naidu, Babu; Nonaka, Daisuke; Peggs, Karl; Pritchard, Catrin; Remmen, Hardy; Rowan, Andrew; Shah, Rajesh; Smith, Elaine; Summers, Yvonne; Taylor, Magali; Veeriah, Selvaraju; Waller, David; Wilcox, Ben; Wilcox, Maggie; Woolhouse, Ian; McGranahan, Nicholas; Swanton, Charles (Corresponding Author).

In: PLoS Biology, Vol. 12, No. 7, e1001906, 08.07.2014, p. 1-7.

Research output: Contribution to journalArticle

Jamal-Hanjani, M, Hackshaw, A, Ngai, Y, Shaw, J, Dive, C, Quezada, S, Middleton, G, de Bruin, E, Le Quesne, J, Shafi, S, Falzon, M, Horswell, S, Blackhall, F, Khan, I, Janes, S, Nicolson, M, Lawrence, D, Forster, M, Fennell, D, Lee, SM, Lester, J, Kerr, K, Muller, S, Iles, N, Smith, S, Murugaesu, N, Mitter, R, Salm, M, Stuart, A, Matthews, N, Adams, H, Ahmad, T, Attanoos, R, Bennett, J, Birkbak, NJ, Booton, R, Brady, G, Buchan, K, Capitano, A, Chetty, M, Cobbold, M, Crosbie, P, Davies, H, Denison, A, Djearman, M, Goldman, J, Haswell, T, Joseph, L, Kornaszewska, M, Krebs, M, Langman, G, MacKenzie, M, Millar, J, Morgan, B, Naidu, B, Nonaka, D, Peggs, K, Pritchard, C, Remmen, H, Rowan, A, Shah, R, Smith, E, Summers, Y, Taylor, M, Veeriah, S, Waller, D, Wilcox, B, Wilcox, M, Woolhouse, I, McGranahan, N & Swanton, C 2014, 'Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study', PLoS Biology, vol. 12, no. 7, e1001906, pp. 1-7. https://doi.org/10.1371/journal.pbio.1001906
Jamal-Hanjani M, Hackshaw A, Ngai Y, Shaw J, Dive C, Quezada S et al. Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study. PLoS Biology. 2014 Jul 8;12(7):1-7. e1001906. https://doi.org/10.1371/journal.pbio.1001906
Jamal-Hanjani, Mariam ; Hackshaw, Alan ; Ngai, Yenting ; Shaw, Jacqueline ; Dive, Caroline ; Quezada, Sergio ; Middleton, Gary ; de Bruin, Elza ; Le Quesne, John ; Shafi, Seema ; Falzon, Mary ; Horswell, Stuart ; Blackhall, Fiona ; Khan, Iftekhar ; Janes, Sam ; Nicolson, Marianne ; Lawrence, David ; Forster, Martin ; Fennell, Dean ; Lee, Siow Ming ; Lester, Jason ; Kerr, Keith ; Muller, Salli ; Iles, Natasha ; Smith, Sean ; Murugaesu, Nirupa ; Mitter, Richard ; Salm, Max ; Stuart, Aengus ; Matthews, Nik ; Adams, Haydn ; Ahmad, Tanya ; Attanoos, Richard ; Bennett, Jonathan ; Birkbak, Nicolai Juul ; Booton, Richard ; Brady, Ged ; Buchan, Keith ; Capitano, Arrigo ; Chetty, Mahendran ; Cobbold, Mark ; Crosbie, Philip ; Davies, Helen ; Denison, Alan ; Djearman, Madhav ; Goldman, Jacki ; Haswell, Tom ; Joseph, Leena ; Kornaszewska, Malgorzata ; Krebs, Matthew ; Langman, Gerald ; MacKenzie, Mairead ; Millar, Joy ; Morgan, Bruno ; Naidu, Babu ; Nonaka, Daisuke ; Peggs, Karl ; Pritchard, Catrin ; Remmen, Hardy ; Rowan, Andrew ; Shah, Rajesh ; Smith, Elaine ; Summers, Yvonne ; Taylor, Magali ; Veeriah, Selvaraju ; Waller, David ; Wilcox, Ben ; Wilcox, Maggie ; Woolhouse, Ian ; McGranahan, Nicholas ; Swanton, Charles. / Tracking Genomic Cancer Evolution for Precision Medicine : The Lung TRACERx Study. In: PLoS Biology. 2014 ; Vol. 12, No. 7. pp. 1-7.
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abstract = "The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.",
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