Tracking Parkinson's

Study Design and Baseline Patient Data

Naveed Malek, Diane M A Swallow, Katherine A Grosset, Michael A Lawton, Sarah L Marrinan, Alexander C Lehn, Catherine Bresner, Nin Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Thomas Foltynie, John Hardy, Huw R Morris, Nigel M Williams, Nicholas Wood, Donald G Grosset, PRoBaND

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.

OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.

METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset PD. We present here baseline clinical data from this large and demographically representative cohort.

RESULTS: 2247 PD cases were recruited (1987 recent onset, 260 young onset). Recent onset cases had a mean (standard deviation, SD) age of 67.6 years (9.3) at study entry, 65.7% males, with disease duration 1.3 years (0.9), MDS-UPDRS 3 scores 22.9 (12.3), LEDD 295 mg/day (211) and PDQ-8 score 5.9 (4.8). Young onset cases were 53.5 years old (7.8) at study entry, 66.9% male, with disease duration 10.2 years (6.7), MDS-UPDRS 3 scores 27.4 (15.3), LEDD 926 mg/day (567) and PDQ-8 score 11.6 (6.1).

CONCLUSIONS: We have established a large clinical PD cohort, consisting of young onset and recent onset cases, which is designed to evaluate variation in clinical expression, in relation to genetic influences, and which offers a platform for future imaging and biomarker research.

Original languageEnglish
Pages (from-to)947-959
Number of pages13
Journal Journal of Parkinson's Disease
Volume5
Issue number4
DOIs
Publication statusPublished - 2015

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Parkinson Disease
Biomarkers
Epidemiologic Studies
Quality of Life
Phenotype
Research

Keywords

  • Adult
  • Age of Onset
  • Aged
  • Female
  • Follow-Up Studies
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease
  • Phenotype
  • Research Design
  • Journal Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

Cite this

Malek, N., Swallow, D. M. A., Grosset, K. A., Lawton, M. A., Marrinan, S. L., Lehn, A. C., ... PRoBaND (2015). Tracking Parkinson's: Study Design and Baseline Patient Data. Journal of Parkinson's Disease, 5(4), 947-959. https://doi.org/10.3233/JPD-150662

Tracking Parkinson's : Study Design and Baseline Patient Data. / Malek, Naveed; Swallow, Diane M A; Grosset, Katherine A; Lawton, Michael A; Marrinan, Sarah L; Lehn, Alexander C; Bresner, Catherine; Bajaj, Nin; Barker, Roger A; Ben-Shlomo, Yoav; Burn, David J; Foltynie, Thomas; Hardy, John; Morris, Huw R; Williams, Nigel M; Wood, Nicholas; Grosset, Donald G; PRoBaND.

In: Journal of Parkinson's Disease, Vol. 5, No. 4, 2015, p. 947-959.

Research output: Contribution to journalArticle

Malek, N, Swallow, DMA, Grosset, KA, Lawton, MA, Marrinan, SL, Lehn, AC, Bresner, C, Bajaj, N, Barker, RA, Ben-Shlomo, Y, Burn, DJ, Foltynie, T, Hardy, J, Morris, HR, Williams, NM, Wood, N, Grosset, DG & PRoBaND 2015, 'Tracking Parkinson's: Study Design and Baseline Patient Data', Journal of Parkinson's Disease, vol. 5, no. 4, pp. 947-959. https://doi.org/10.3233/JPD-150662
Malek, Naveed ; Swallow, Diane M A ; Grosset, Katherine A ; Lawton, Michael A ; Marrinan, Sarah L ; Lehn, Alexander C ; Bresner, Catherine ; Bajaj, Nin ; Barker, Roger A ; Ben-Shlomo, Yoav ; Burn, David J ; Foltynie, Thomas ; Hardy, John ; Morris, Huw R ; Williams, Nigel M ; Wood, Nicholas ; Grosset, Donald G ; PRoBaND. / Tracking Parkinson's : Study Design and Baseline Patient Data. In: Journal of Parkinson's Disease. 2015 ; Vol. 5, No. 4. pp. 947-959.
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AU - Malek, Naveed

AU - Swallow, Diane M A

AU - Grosset, Katherine A

AU - Lawton, Michael A

AU - Marrinan, Sarah L

AU - Lehn, Alexander C

AU - Bresner, Catherine

AU - Bajaj, Nin

AU - Barker, Roger A

AU - Ben-Shlomo, Yoav

AU - Burn, David J

AU - Foltynie, Thomas

AU - Hardy, John

AU - Morris, Huw R

AU - Williams, Nigel M

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KW - Phenotype

KW - Research Design

KW - Journal Article

KW - Multicenter Study

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