Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar)

L. Tacchi, A. Douglas, C. J. Secombes, R. Bickerdike, S. A. M. Martin

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Functional feeds are diets that have positive effects on both health and growth promoting performance of the animals ingesting them, by supplying additional compounds above and beyond the basic nutritional requirements for animal growth alone. The most common additives used in aquaculture diets are probiotics, prebiotics, immunostimulants, vitamins and nucleotides. Inclusion of these components to fish diets can increase feed conversion efficiency and growth, as well as having positive effects on the fish immune system. This review discusses the results from previous studies on fish nutrition and includes a novel genomic approach, using microarray analysis, to elucidate nutritional responses in Atlantic salmon (Salmo salar) fed a newly developed functional feed health premix diet. The transcriptome analysis demonstrated that compared to the standard diet feeding with the functional feed had significant effects on biological processes in the liver. This resulted in a reduction of the expression of genes related to protein turnover, reduced circulating plasma proteins and a down regulation of genes involved in the immune response. These results suggest that the functional feed may infer a decrease in whole body metabolic demands, suppressing both protein turnover and whole body oxygen demand, as well as down regulating several genes involved in the innate immune system. Together these changes appear to result in less energy wastage in fish and an enhanced growth and performance.
Original languageEnglish
Pages (from-to)704-715
Number of pages12
JournalFish & Shellfish Immunology
Volume31
Issue number5
Early online date4 Mar 2011
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Nutrition
transcriptomics
Salmo salar
diet
Fish
immune system
fish
protein metabolism
Genes
Immune system
protein
gene
turnover
fish nutrition
Animals
immunostimulants
nutritional requirement
animal growth
Health
probiotics

Keywords

  • Atlantic salmon
  • aquaculture
  • immunology
  • microarray
  • functional feed

Cite this

Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar). / Tacchi, L.; Douglas, A.; Secombes, C. J.; Bickerdike, R.; Martin, S. A. M.

In: Fish & Shellfish Immunology, Vol. 31, No. 5, 11.2011, p. 704-715.

Research output: Contribution to journalArticle

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