Transgenerational Effects of Parental Diet on Offspring Development and Disease Resistance in Flies

Hue Dinh; Binh Nguyen; Juliano Morimoto; Ida Lundback; Sheemal S. Kumar; Fleur Ponton

doi:10.3389/fevo.2021.606993

Transgenerational Effects of Parental Diet on Offspring Development and Disease Resistance in Flies

Hue Dinh, Binh Nguyen, Juliano Morimoto, Ida Lundback, Sheemal S. Kumar, Fleur Ponton^*

^*Corresponding author for this work

Aberdeen Centre For Environmental Sustainability

Macquarie University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

6 Downloads (Pure)

Abstract

The environmental conditions experienced by parents influence next generations, with the parental nutritional status playing an important role in shaping offspring phenotypes. Our understanding of transgenerational effects of parental diet on offspring pathogen resistance is, however, poorly documented. We manipulated the quality of parental diet (i.e., mother, father, or both) and measured effects on offspring development and survival after an immune challenge by septic infection. We used Bactrocera tryoni as host model infected with the pathogenic bacterium, Serratia marcescens. Our results showed no significant effect of maternal, or paternal, diet on offspring resistance. Interestingly, when the diet of both parents was manipulated, sons from parents fed either carbohydrate- or protein-biased diets had higher survival upon pathogen infection than sons from parents fed balanced diets. The quality of the parental diet had no effect on offspring developmental traits with the exception of egg hatching percentage which decreased when mothers were fed a protein-biased diet. Our results emphasised the complexity of nutritional transgenerational effects on offspring pathogen resistance and development.

Original language	English
Article number	606993
Number of pages	9
Journal	Frontiers in Ecology and Evolution
Volume	9
DOIs	https://doi.org/10.3389/fevo.2021.606993
Publication status	Published - 28 Jun 2021

Bibliographical note

Funding Information:
This research was conducted as part of the SITplus collaborative fruit fly program. Project Raising Q-fly Sterile Insect Technique to World Standard (HG14033) is funded by the Hort Frontiers Fruit Fly Fund, part of the Hort Frontiers strategic partnership initiative developed by Hort Innovation, with co-investment from Macquarie University and contributions from the Australian Government. HD was supported by Macquarie University Research Excellence Scholarship. BN was funded by the international Research Training Program (iRTP) scholarship from Macquarie University (NSW, Australia).

Publisher Copyright:
© Copyright © 2021 Dinh, Nguyen, Morimoto, Lundback, Kumar and Ponton.

Keywords

development
disease resistance
offspring
parental diet
Serratia marcescens
transgenerational effects

Access to Document

10.3389/fevo.2021.606993Licence: CC BY

Dinh_etal_fevo_Transgenerational_Effects_Parental_VOR
Copyright © 2021 Dinh, Nguyen, Morimoto, Lundback, Kumar and Ponton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. https://creativecommons.org/licenses/by/4.0/
Final published version, 3.39 MBLicence: CC BY

Cite this

@article{c028584c02ad4c9d9065a7db448a4587,

title = "Transgenerational Effects of Parental Diet on Offspring Development and Disease Resistance in Flies",

abstract = "The environmental conditions experienced by parents influence next generations, with the parental nutritional status playing an important role in shaping offspring phenotypes. Our understanding of transgenerational effects of parental diet on offspring pathogen resistance is, however, poorly documented. We manipulated the quality of parental diet (i.e., mother, father, or both) and measured effects on offspring development and survival after an immune challenge by septic infection. We used Bactrocera tryoni as host model infected with the pathogenic bacterium, Serratia marcescens. Our results showed no significant effect of maternal, or paternal, diet on offspring resistance. Interestingly, when the diet of both parents was manipulated, sons from parents fed either carbohydrate- or protein-biased diets had higher survival upon pathogen infection than sons from parents fed balanced diets. The quality of the parental diet had no effect on offspring developmental traits with the exception of egg hatching percentage which decreased when mothers were fed a protein-biased diet. Our results emphasised the complexity of nutritional transgenerational effects on offspring pathogen resistance and development.",

keywords = "development, disease resistance, offspring, parental diet, Serratia marcescens, transgenerational effects",

author = "Hue Dinh and Binh Nguyen and Juliano Morimoto and Ida Lundback and Kumar, {Sheemal S.} and Fleur Ponton",

note = "Funding Information: This research was conducted as part of the SITplus collaborative fruit fly program. Project Raising Q-fly Sterile Insect Technique to World Standard (HG14033) is funded by the Hort Frontiers Fruit Fly Fund, part of the Hort Frontiers strategic partnership initiative developed by Hort Innovation, with co-investment from Macquarie University and contributions from the Australian Government. HD was supported by Macquarie University Research Excellence Scholarship. BN was funded by the international Research Training Program (iRTP) scholarship from Macquarie University (NSW, Australia). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Dinh, Nguyen, Morimoto, Lundback, Kumar and Ponton.",

year = "2021",

month = jun,

day = "28",

doi = "10.3389/fevo.2021.606993",

language = "English",

volume = "9",

journal = "Frontiers in Ecology and Evolution",

issn = "2296-701X",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Transgenerational Effects of Parental Diet on Offspring Development and Disease Resistance in Flies

AU - Dinh, Hue

AU - Nguyen, Binh

AU - Morimoto, Juliano

AU - Lundback, Ida

AU - Kumar, Sheemal S.

AU - Ponton, Fleur

N1 - Funding Information: This research was conducted as part of the SITplus collaborative fruit fly program. Project Raising Q-fly Sterile Insect Technique to World Standard (HG14033) is funded by the Hort Frontiers Fruit Fly Fund, part of the Hort Frontiers strategic partnership initiative developed by Hort Innovation, with co-investment from Macquarie University and contributions from the Australian Government. HD was supported by Macquarie University Research Excellence Scholarship. BN was funded by the international Research Training Program (iRTP) scholarship from Macquarie University (NSW, Australia). Publisher Copyright: © Copyright © 2021 Dinh, Nguyen, Morimoto, Lundback, Kumar and Ponton.

PY - 2021/6/28

Y1 - 2021/6/28

N2 - The environmental conditions experienced by parents influence next generations, with the parental nutritional status playing an important role in shaping offspring phenotypes. Our understanding of transgenerational effects of parental diet on offspring pathogen resistance is, however, poorly documented. We manipulated the quality of parental diet (i.e., mother, father, or both) and measured effects on offspring development and survival after an immune challenge by septic infection. We used Bactrocera tryoni as host model infected with the pathogenic bacterium, Serratia marcescens. Our results showed no significant effect of maternal, or paternal, diet on offspring resistance. Interestingly, when the diet of both parents was manipulated, sons from parents fed either carbohydrate- or protein-biased diets had higher survival upon pathogen infection than sons from parents fed balanced diets. The quality of the parental diet had no effect on offspring developmental traits with the exception of egg hatching percentage which decreased when mothers were fed a protein-biased diet. Our results emphasised the complexity of nutritional transgenerational effects on offspring pathogen resistance and development.

AB - The environmental conditions experienced by parents influence next generations, with the parental nutritional status playing an important role in shaping offspring phenotypes. Our understanding of transgenerational effects of parental diet on offspring pathogen resistance is, however, poorly documented. We manipulated the quality of parental diet (i.e., mother, father, or both) and measured effects on offspring development and survival after an immune challenge by septic infection. We used Bactrocera tryoni as host model infected with the pathogenic bacterium, Serratia marcescens. Our results showed no significant effect of maternal, or paternal, diet on offspring resistance. Interestingly, when the diet of both parents was manipulated, sons from parents fed either carbohydrate- or protein-biased diets had higher survival upon pathogen infection than sons from parents fed balanced diets. The quality of the parental diet had no effect on offspring developmental traits with the exception of egg hatching percentage which decreased when mothers were fed a protein-biased diet. Our results emphasised the complexity of nutritional transgenerational effects on offspring pathogen resistance and development.

KW - development

KW - disease resistance

KW - offspring

KW - parental diet

KW - Serratia marcescens

KW - transgenerational effects

UR - http://www.scopus.com/inward/record.url?scp=85109924247&partnerID=8YFLogxK

U2 - 10.3389/fevo.2021.606993

DO - 10.3389/fevo.2021.606993

M3 - Article

AN - SCOPUS:85109924247

SN - 2296-701X

VL - 9

JO - Frontiers in Ecology and Evolution

JF - Frontiers in Ecology and Evolution

M1 - 606993

ER -

Transgenerational Effects of Parental Diet on Offspring Development and Disease Resistance in Flies

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this