Translational control of gene expression via interacting feedback loops

Liang Wang, M. Carmen Romano, Fordyce A. Davidson*

*Corresponding author for this work

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Abstract

Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multicomponent mathematical framework we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step change, and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.
Original languageEnglish
Article number050402(R)
Number of pages6
JournalPhysical Review. E, Statistical, Nonlinear and Soft Matter Physics
Volume100
Issue number5
DOIs
Publication statusPublished - 26 Nov 2019

Keywords

  • ASYMMETRIC EXCLUSION MODEL
  • AUTOREGULATION
  • DYNAMICS
  • EUKARYOTIC MESSENGER-RNA
  • POLY(A)-BINDING PROTEIN

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Statistics and Probability

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