Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multicomponent mathematical framework we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step change, and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.
|Number of pages||6|
|Journal||Physical Review. E, Statistical, Nonlinear and Soft Matter Physics|
|Publication status||Published - 26 Nov 2019|
- ASYMMETRIC EXCLUSION MODEL
- EUKARYOTIC MESSENGER-RNA
- POLY(A)-BINDING PROTEIN
FingerprintDive into the research topics of 'Translational control of gene expression via interacting feedback loops'. Together they form a unique fingerprint.
- School of Natural & Computing Sciences, Physics - Personal Chair
- Institute for Complex Systems and Mathematical Biology (ICSMB)